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Titolo:
Telomere length as an indicator of biological aging - The gender effect and relation with pulse pressure and pulse wave velocity
Autore:
Benetos, A; Okuda, K; Lajemi, M; Kimura, M; Thomas, F; Skurnick, J; Labat, C; Bean, K; Aviv, A;
Indirizzi:
IPC Ctr, F-75116 Paris, France IPC Ctr Paris France F-75116IPC Ctr, F-75116 Paris, France INSERM, U337, Paris, France INSERM Paris FranceINSERM, U337, Paris, France Univ Med & Dent New Jersey, Hypertens Res Ctr, Newark, NJ 07103 USA Univ Med & Dent New Jersey Newark NJ USA 07103 Ctr, Newark, NJ 07103 USA Univ Med & Dent New Jersey, Dept Prevent Med & Community Hlth, Newark, NJ 07103 USA Univ Med & Dent New Jersey Newark NJ USA 07103 Hlth, Newark, NJ 07103 USA
Titolo Testata:
HYPERTENSION
fascicolo: 2, volume: 37, anno: 2001,
parte:, 2 supplemento:, S
pagine: 381 - 385
SICI:
0194-911X(200102)37:2<381:TLAAIO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR MORTALITY; ARTERIAL DISTENSIBILITY; AORTIC STIFFNESS; AGE; HYPERTENSION; POPULATION; DISEASE;
Keywords:
blood pressure; aorta; genetics; aging; sex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Benetos, A IPC Ctr, 6-14 Rue Perouse, F-75116 Paris, France IPC Ctr 6-14 Rue Perouse Paris France F-75116 16 Paris, France
Citazione:
A. Benetos et al., "Telomere length as an indicator of biological aging - The gender effect and relation with pulse pressure and pulse wave velocity", HYPERTENSIO, 37(2), 2001, pp. 381-385

Abstract

Chronological age is the primary determinant of stiffness of central arteries. Increased stiffness is an independent indicator of cardiovascular risk. The aim of this study was to determine whether telomere length, a possible index of biological aging, provides a better account than chronological age for variation in arterial stiffness, evaluated by measuring pulse pressure and aortic pulse wave velocity. The study population included 193 Frenchsubjects (120 men, 73 women), with a mean age of 56+/-11 years, who were not on any antihypertensive medications. Telomere length was evaluated in white blood cells by measuring the mean length of the terminal restriction fragments. Age-adjusted telomere length was longer in women than in men (8.67/-0.09 versus 8.37+/-0.07 kb; P=0.016). In both genders, telomere length was inversely correlated with age (P<0.01). Multivariate analysis showed that in men, but not in women, telomere length significantly contributed to pulse pressure and pulse wave velocity variations. In conclusion, telomere length provides an additional account to chronological age of variations in both pulse pressure and pulse wave velocity among men, such that men with shorter telomere length are more likely to exhibit high pulse pressure and pulse wave velocity, which are indices of large artery stiffness. The longer telomere length in women suggests that for a given chronological age, biological aging of men is more advanced than that of women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:51:50