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Titolo:
Pulse pressure, aortic reactivity, and endothelium dysfunction in old hypertensive rats
Autore:
Chamiot-Clerc, P; Renaud, JF; Safar, ME;
Indirizzi:
Hop Broussais, Dept Internal Med, F-75674 Paris 14, France Hop Broussais Paris France 14 ept Internal Med, F-75674 Paris 14, France Hop Broussais, INSERM, U337, F-75674 Paris, France Hop Broussais Paris France F-75674 , INSERM, U337, F-75674 Paris, France Hop Marie Lannelongue, Dept Med Res, CNRS, F-92350 Le Plessis Robinson, France Hop Marie Lannelongue Le Plessis Robinson France F-92350 obinson, France
Titolo Testata:
HYPERTENSION
fascicolo: 2, volume: 37, anno: 2001,
pagine: 313 - 321
SICI:
0194-911X(200102)37:2<313:PPARAE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITION; AGE-RELATED-CHANGES; NITRIC-OXIDE; MECHANICAL-PROPERTIES; CAROTID-ARTERY; WALL; EXPRESSION; RELAXATION; STRESS; YOUNG;
Keywords:
rats, spontaneously hypertensive; arteries; endothelium; pulse pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Safar, ME Hop Broussais, Dept Internal Med, 96 Rue Didot, F-75674 Paris 14, France Hop Broussais 96 Rue Didot Paris France 14 674 Paris 14, France
Citazione:
P. Chamiot-Clerc et al., "Pulse pressure, aortic reactivity, and endothelium dysfunction in old hypertensive rats", HYPERTENSIO, 37(2), 2001, pp. 313-321

Abstract

The reactivity of old hypertensive rat aortas has not been investigated inrelation to each phenotype of the blood pressure curve, mean arterial pressure (MAP), and pulse pressure (PP). Aortic reactivities from 3- to 78-week-old Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) werestudied with the use of organ chambers and invasive blood pressure, carotid diameter, and histomorphometry. MAP and PP were elevated in SHR, but at 78 weeks, a selective increase of PP without further MAP increase was observed for the same carotid diameter as WKY. Aortic relaxation in response to carbamylcholine decreased similarly with age in both strains. With (+) or without (-) endothelium (E), maximal developed tension (MDT) under KCl increased linearly with age in SHR, proportionally to wall thickness and MAP increase. Under norepinephrine (NE), MDT of E- aortas from SHR and controls increased with age and reached plateaus at 12 weeks, whereas MDT of E+ aortas from SHR increased linearly with age. Because the NE-induced MDT was higherfor E- than E+, the difference estimated endothelial function. This difference reached plateaus from 12 to 78 weeks in WKY but was abolished beyond 12 weeks in SHR, a finding also observed under NO-synthase inhibition. In old hypertensive rats, (1) increased KCl reactivity is endothelium independent but influenced by the MAP-dependent aortic hypertrophy with resulting increased vascular smooth muscle reactivity, whereas (2) increased NE reactivity is endothelium dependent in association with increased PP, altered endothelial function, and extracellular matrix, with resulting enhanced intrinsic arterial stiffness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:43:42