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Titolo:
Sleep laboratory studies in periodic limb movement disorder (PLMD) patients as compared with normals and acute effects of ropinirole
Autore:
Saletu, M; Anderer, P; Saletu, B; Hauer, C; Mandl, M; Semler, B; Saletu-Zyhlarz, G;
Indirizzi:
Univ Vienna, Dept Psychiat, Sect Sleep Res & Pharmacopsychiat, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 armacopsychiat, A-1010 Vienna, Austria Sleep Lab Rudolfinerhaus, Vienna, Austria Sleep Lab Rudolfinerhaus Vienna Austria Rudolfinerhaus, Vienna, Austria
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 2, volume: 16, anno: 2001,
pagine: 177 - 187
SICI:
0885-6222(200103)16:2<177:SLSIPL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTLESS LEGS SYNDROME; EARLY PARKINSONS-DISEASE; DOUBLE-BLIND; NOCTURNAL MYOCLONUS; L-DOPA; CROSSOVER TRIAL; F-18 DOPA; LEVODOPA; PLACEBO; BROMOCRIPTINE;
Keywords:
dopamine agonist; first night effect; periodic limb movement disorder; polysomnography; ropinirole; subjective sleep and awakening quality;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Saletu, M Innsbruck Univ, Dept Neurol, Sect Sleep Res, Anichstr 35, A-6020Innsbruck, Austria Innsbruck Univ Anichstr 35 Innsbruck Austria A-6020 ck, Austria
Citazione:
M. Saletu et al., "Sleep laboratory studies in periodic limb movement disorder (PLMD) patients as compared with normals and acute effects of ropinirole", HUM PSYCHOP, 16(2), 2001, pp. 177-187

Abstract

Periodic limb movement disorder (PLMD) occurs in a variety of sleep disorders and can cause insomnia as well as hypersomnia with daytime somnolence. The aim of this study was to investigate 12 untreated PLMD patients as compared with 12 normal controls and to measure the acute effects of 0.5 mg ropinirole (Requip (R)) - a non-ergoline dopamine agonist - as compared with placebo. In three nights (adaptation, placebo, ropinirole night) objective and subjective sleep and awakening quality were evaluated. In the target variable 'periodic leg movements per hour of sleep' (PLM/(hTST)) PLMD patientsshowed an increased value of 42/h (normal 0-5/h) with a greater number of arousals due to periodic leg movements (PLM) in sleep. They further demonstrated an increased number of awakenings, sleep stage S1, S4, stage shifts and decreased S2, but there were no significant differences concerning totalsleep time, sleep efficiency (SE), subjective sleep quality and morning measures of mead, drive and drowsiness. However, measures of attention variability, numerical memory, fine motor activity and reaction time performance were impaired. Ropinirole 0.5 mg was shown to significantly improve the index PLM/(hTST) by 64% and arousals due to PLM, increase spontaneous arousals, REM-latency, stage 2 and stage shifts and decrease SREM. In the morning attention variability was attenuated and numerical memory augmented. Thus, ropinirole improved some sleep architecture and early morning measures of performance but specifically all PLM variables, which suggests a dopaminergicpathogenesis in PLMD. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:11:34