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Titolo:
Residual effects of zaleplon and zolpidem following middle of the night administration five hours to one hour before awakening
Autore:
Hindmarch, I; Patat, A; Stanley, N; Paty, I; Rigney, U;
Indirizzi:
Univ Surrey, HPRU Med Res Ctr, Guildford GU2 7XP, Surrey, England Univ Surrey Guildford Surrey England GU2 7XP ord GU2 7XP, Surrey, England Wyeth Ayerst Res, Paris, France Wyeth Ayerst Res Paris FranceWyeth Ayerst Res, Paris, France
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 2, volume: 16, anno: 2001,
pagine: 159 - 167
SICI:
0885-6222(200103)16:2<159:REOZAZ>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHOMOTOR PERFORMANCE; HEALTHY-VOLUNTEERS; INSOMNIA; MEMORY; SLEEP; BENZODIAZEPINES; PHARMACOLOGY; PLACEBO; DRUGS; TRIAZOLAM;
Keywords:
choice reaction time; critical flicker fusion; digit symbol substitution test; zaleplon; zolpidem;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hindmarch, I Univ Surrey, HPRU Med Res Ctr, Egerton Rd, Guildford GU2 7XP,Surrey, England Univ Surrey Egerton Rd Guildford Surrey England GU2 7XP gland
Citazione:
I. Hindmarch et al., "Residual effects of zaleplon and zolpidem following middle of the night administration five hours to one hour before awakening", HUM PSYCHOP, 16(2), 2001, pp. 159-167

Abstract

The objective was to assess residual effects of zaleplon and zolpidem after a middle of the night administration. This was a randomized, double-blind, placebo-controlled, crossover study, conducted in 40 healthy young male and female subjects. Subjects were awakened in the middle of the night and administered either placebo or zaleplon 10 or 20 mg or zolpidem 10 mg. A battery of objective tests exploring psychomotor and cognitive functions such as critical flicker fusion (CFF), choice rection time (CRT), digit symbol substitution test (DSST), and memory tests (Sternberg memory scanning and a word list) were administered immediately after morning waking. Zaleplon 10 mg was devoid of residual effects whatever - the time of dosing - except a minimal but significant decrease in DSST scores when administered 1 h before awakening. Zaleplon 20 mg produced significant 'residual effects on performance (increase in CRT, and decrease in CFF threshold and in DSST scores) and memory (decrease in immediate and delayed free recall of words) only when administered Ih before awakening. In contrast, zolpidem 10 mg produced significant detrimental residual effects on CRT and delayed free recall of words, when administered up to 5 h before waking, on DSST and Sternberg whenadministered up to 3 h before awakening and on CFF when administered 1 h before awakening. The residual effects of zolpidem 10 mg were more marked than those observed after zaleplon 20 mg. The present results demonstrate that zaleplon 10 mg has no or minimal residual effects when administered in the middle of the night as little as 1 h before waking. The lack of clinically significant residual effects with zaleplon may be explained by its uniquepharmacokinetic (rapid elimination half-life) and pharmacodynamic (selective binding for GABAA receptors with the al subunit, dissociation between sleep inducing properties and impairment of cognitive functions) profiles. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:02:09