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Titolo:
Strategies for the rapid treatment of depression
Autore:
Miller, FE;
Indirizzi:
Northwestern Univ, Sch Med, Evanston NW Healthcare, Evanston, IL 60201 USANorthwestern Univ Evanston IL USA 60201 ealthcare, Evanston, IL 60201 USA
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 2, volume: 16, anno: 2001,
pagine: 125 - 132
SICI:
0885-6222(200103)16:2<125:SFTRTO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; TRUE DRUG RESPONSE; MAJOR DEPRESSION; DOUBLE-BLIND; ANTIDEPRESSANT AUGMENTATION; PATTERN-ANALYSIS; PINDOLOL; ONSET; VENLAFAXINE; FLUOXETINE;
Keywords:
accelerating; antidepressant; rapid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, FE Northwestern Univ, Sch Med, Evanston NW Healthcare, 2650 Ridge Ave, Evanston, IL 60201 USA Northwestern Univ 2650 Ridge Ave Evanston IL USA 60201 0201 USA
Citazione:
F.E. Miller, "Strategies for the rapid treatment of depression", HUM PSYCHOP, 16(2), 2001, pp. 125-132

Abstract

The purpose of this article is to review current literature relating to the determination of the time course of antidepressant effects. Further, thiswork explores studies examining the safety and effectiveness of pharmacological techniques for accelerating the therapeutic effects of antidepressantmedication. A review of the literature pertaining to strategies for accelerating antidepressant medication effects was accomplished using the MEDLINEdatabase, employing the key title words, antidepressant, rapid, and accelerating. A preponderance of evidence suggests that there is a multiple week latency for the onset of action of antidepressant medications. This latencyappears to apply to virtually all standard antidepressants and may reflectslow adaptive changes to the inciting event of increased monoamine levels. Several strategies have received attention as potential strategies with which to accelerate the therapeutic effects of antidepressant medications. These include the use of high initial doses of some agents and also the use of initial augmentation strategies. Specifically, studies exist suggesting the acceleration of antidepressant effects using high initial doses of tricyclic antidepressants or venlafaxine, as well as the potential for acceleration by using initial augmentation with psychostimulants, lithium, or pindolol. Considering the morbidity and mortality associated with severe depression, a critical need exist far the exploration of ways in which to achieve antidepressant effects more quickly. A number of preliminary studies suggeststrategies for the rapid treatment of depression, each with an apparent high degree of safety. Further investigations in more carefully defined patient populations and utilizing advances in the techniques for assessing antidepressant onset are needed. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 03:44:46