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Titolo:
Polymorphism in promoter region of Fc alpha receptor gene in patients withIgA nephropathy
Autore:
Tsuge, T; Shimokawa, T; Horikoshi, S; Tomino, Y; Ra, C;
Indirizzi:
Juntendo Univ, Sch Med, Allergy Res Ctr, Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 s Ctr, Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ, Sch Med, Dept Med, Div Nephrol,Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 ephrol,Bunkyo Ku, Tokyo 1138421, Japan Japan Sci & Technol Corp, JST, CREST, Kawaguchi, Japan Japan Sci & TechnolCorp Kawaguchi Japan , JST, CREST, Kawaguchi, Japan
Titolo Testata:
HUMAN GENETICS
fascicolo: 2, volume: 108, anno: 2001,
pagine: 128 - 133
SICI:
0340-6717(200102)108:2<128:PIPROF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MESANGIAL CELLS; CHAIN SWITCH REGION; R EXPRESSION; POLYMORPHONUCLEAR LEUKOCYTES; SUPEROXIDE GENERATION; JAPANESE PATIENTS; SERUM IGA; CD89; GLOMERULONEPHRITIS; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Ra, C Juntendo Univ, Sch Med, Allergy Res Ctr, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan Juntendo Univ 2-1-1 Hongo Tokyo Japan 1138421 Tokyo 1138421, Japan
Citazione:
T. Tsuge et al., "Polymorphism in promoter region of Fc alpha receptor gene in patients withIgA nephropathy", HUM GENET, 108(2), 2001, pp. 128-133

Abstract

We have recently identified two novel polymorphisms (-114T/C and +56T/C relative to the major transcription start site) in the functional promoter region of the Fc alpha receptor (Fc alphaR) gene. Since altered Fc alphaR expression may be associated with IgA nephropathy, we examined these promoter polymorphisms in this disease. Patients with IgA nephropathy (n=90), patients with other primary glomerulonephritis (n=50), and healthy adults (n=83) were studied. Genotyping was performed by the polymerase chain reaction (PCR) followed by direct sequence analysis and was subsequently confirmed by PCR with mismatched primers followed by restriction fragment length polymorphism analysis. The study demonstrated that the frequency of the +56C allelein patients with IgA nephropathy (0.511) was significantly (P<0.01) higherthan that in patients with other primary glomerulonephritis (0.350) and healthy adults (0.337). In addition, a significant increase in the frequency of the +56CC genotype was observed in patients with IgA nephropathy (27.8% vs 10.0% in other GN and vs 9.6% in healthy adults). In contrast, no significant difference in the frequencies of the +56CC genotype and +56C allele was observed between other primary glomerulonephritis patients and healthy adults. The frequency of the -114CC genotype in patients with IEA nephropathy was significantly increased compared with those in both control groups (15.6% vs 4.0% in other GN and vs 2.4% in healthy adults). Polymorphisms of the Fc<alpha>R promoter region therefore appear to be associated with susceptibility to IgA nephropathy, suggesting the importance of the Fc alphaR gene and its expression in this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:56:11