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Titolo:
The pituitary response to ovine corticotropin-releasing hormone is enhanced in obese men and correlates with insulin resistance
Autore:
Solano, MP; Kumar, M; Fernandez, B; Jones, L; Goldberg, RB;
Indirizzi:
Univ Miami, Sch Med, Dept Med, Miami, FL 33136 USA Univ Miami Miami FL USA 33136 ami, Sch Med, Dept Med, Miami, FL 33136 USA Univ Miami, Sch Med, Dept Psychiat & Behav Sci, Miami, FL USA Univ Miami Miami FL USA ch Med, Dept Psychiat & Behav Sci, Miami, FL USA
Titolo Testata:
HORMONE AND METABOLIC RESEARCH
fascicolo: 1, volume: 33, anno: 2001,
pagine: 39 - 43
SICI:
0018-5043(200101)33:1<39:TPRTOC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-FAT DISTRIBUTION; POLYCYSTIC-OVARY-SYNDROME; ADRENAL AXIS ACTIVITY; PLASMA LEPTIN; CORTISOL SECRETION; ABDOMINAL OBESITY; ENERGY-BALANCE; INHIBITION; STRESS; WOMEN;
Keywords:
HPA axis; insulin resistance; central obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Solano, MP Univ Miami, Sch Med, Dept Med, 1450 NW 10th Ave R-77, Miami, FL33136 USA Univ Miami 1450 NW 10th Ave R-77 Miami FL USA 33136 L 33136 USA
Citazione:
M.P. Solano et al., "The pituitary response to ovine corticotropin-releasing hormone is enhanced in obese men and correlates with insulin resistance", HORMONE MET, 33(1), 2001, pp. 39-43

Abstract

Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis in central obesity has been demonstrated in women. We studied the corticotropin (ACTH)and cortisol response to ovine corticotropin releasing hormone (oCRH) and its association to parameters of adiposity and insulin resistance in a group of 19 healthy obese (BMI > 25 kg/m(2)) and 9 non-obese men. Relative insulin resistance was assessed by the homeostatic model assessment (HOMA IR). Baseline ACTH was similar, while cortisol was lower in the obese group, TheACTH response to oCRH was significantly higher in the obese group. ACTH incremental area under the curve (iAUC) correlated with age, HOMA IR, and sagittal diameter but not with leptin. In multiple regression analysis, only HOMA IR was an independent predictor of ACTH iAUC. In conclusion, obese men have hyperactivity of the HPA axis at the pituitary level, which appears tobe linked to insulin resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:17:34