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Titolo:
FR128998 ameliorates liver injury in extended liver resection with ischemia in dogs
Autore:
Iwazaki, S; Takeyoshi, I; Ohwada, S; Sunose, Y; Tsutsumi, H; Kawashima, Y; Matsumoto, K; Morishita, Y;
Indirizzi:
Gunma Univ, Sch Med, Dept Surg 2, Maebashi, Gumma 371, Japan Gunma Univ Maebashi Gumma Japan 371 pt Surg 2, Maebashi, Gumma 371, Japan Nippon Med Sch, Dept Pathol, Kanagawa, Japan Nippon Med Sch Kanagawa Japan pon Med Sch, Dept Pathol, Kanagawa, Japan
Titolo Testata:
HEPATO-GASTROENTEROLOGY
fascicolo: 37, volume: 48, anno: 2001,
pagine: 197 - 202
SICI:
0172-6390(200101/02)48:37<197:FALIIE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING-FACTOR; HEPATIC INFLOW OCCLUSION; PAF-RECEPTOR ANTAGONIST; MYOCARDIAL-ISCHEMIA; REPERFUSION; RATS; INVOLVEMENT; MODULATION; MECHANISMS; RESPONSES;
Keywords:
platelet-activating factor; ischemia-reperfusion injury; extended liver resection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Iwazaki, S 3-39-15 Showa Machi, Maebashi, Gumma 3718511, Japan 3-39-15 Showa Machi Maebashi Gumma Japan 3718511 718511, Japan
Citazione:
S. Iwazaki et al., "FR128998 ameliorates liver injury in extended liver resection with ischemia in dogs", HEP-GASTRO, 48(37), 2001, pp. 197-202

Abstract

Background/Aims: Platelet-activating factor is one of the most potent phospholipid mediators associated with inflammatory conditions such as ischemiaand reperfusion injury, FR128998 (FR) is a novel platelet-activating factor receptor antagonist. In this study, we evaluated the effect of FR during an extended liver resection with ischemia in a canine model. Methodology: Animals were divided into two groups: the control group (n=8), and the FR-treated group (n=7) in which FR was administered via the portal vein. While the right portal pedicle was clamped for 60min, the left portal branch remained patent to avoid splanchnic congestion. Following reperfusion, 75% of the liver (including the right central, quadrate, left central, left lateral, and papillary lobes) was resected. Hepatic venous blood wascollected to measure GPT, GOT, and LDH levels. Hepatic tissue blood flow was measured by a laser Doppler flow meter. The liver specimen was harvestedfor histological study. Results: GPT, GOT, and LDH levels after reperfusion were significantly (P<0.05) lower in the FR-treated group than in the control group. Hepatic tissue blood flow was maintained significantly (P<0.05) higher in the FR-treated group than in the control group. Histologically, accumulation of polymorphonuclear neutrophils significantly (P<0.05) decreased in the FR-treated group compared with the control group. The a-day survival rate was statistically (P<0.05) better in the FR-treated group than in the control group. Conclusions: FR128998 provides a protective effect for liver parenchyma and sinusoidal endothelial cells during extended Liver resection with ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:49:25