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Titolo:
Cytokine response to human liver ischemia-reperfusion injury during hepatectomy: Marker of injury or surgical stress?
Autore:
Hanazaki, K; Monma, T; Hiraguri, M; Ohmoto, Y; Kajikawa, S; Matsushita, A; Nimura, Y; Koide, N; Adachi, W; Amano, J;
Indirizzi:
Shinshu Univ, Sch Med, Dept Surg 2, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan Otsuka Pharmaceut Co Ltd, Cellular Technol Inst, Tokushima, Japan Otsuka Pharmaceut Co Ltd Tokushima Japan Technol Inst, Tokushima, Japan
Titolo Testata:
HEPATO-GASTROENTEROLOGY
fascicolo: 37, volume: 48, anno: 2001,
pagine: 188 - 192
SICI:
0172-6390(200101/02)48:37<188:CRTHLI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINUSOIDAL ENDOTHELIAL-CELLS; COLONY-STIMULATING FACTOR; KETONE-BODY RATIO; PLASMA M-CSF; PRESERVATION INJURY; COLD PRESERVATION; HEPATIC ISCHEMIA; KUPFFER CELLS; LINING CELLS; TRANSPLANTATION;
Keywords:
pringle maneuver; hyaluronic acid; G-CSF; M-CSF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Hanazaki, K Shinshu Univ, Sch Med, Dept Surg 2, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan Shinshu Univ 3-1-1 Asahi Matsumoto Nagano Japan 3908621 Japan
Citazione:
K. Hanazaki et al., "Cytokine response to human liver ischemia-reperfusion injury during hepatectomy: Marker of injury or surgical stress?", HEP-GASTRO, 48(37), 2001, pp. 188-192

Abstract

Background/Aims: The aim of this study was to evaluate the inflammatory orantiinflammatory cytokine response to ischemia-reperfusion during hepatectomy and to find a useful marker of injury or surgical stress during hepaticischemia-reperfusion. Methodology: In 9 patients with liver disease who underwent hepatectomy using the Pringle maneuver, serum cytokines, including alanine transaminase, aspartate transaminase, and hyaluronic acid, were measured just prior to vascular occlusion; 5, 10 and 15min after initial clamping; and 3min after initial declamping. Results: The mean concentrations of aspartate transaminase and alanine transaminase did not significantly differ before and after ischemia-reperfusion during hepatectomy. However, mean concentrations of hyaluronic acid afterischemia-reperfusion were significantly (P<0.03) higher than before clamping. Although there were no significant differences in the mean concentrations of IL-1<beta>, IL-6, IL-8, IL-10 and TNF-alpha among, before and after ischemia-reperfusion, the mean concentrations of granulocyte colony-stimulating factor after ischemia-reperfusion and macrophage colony-stimulating factor after reperfusion were significantly (P<0.05) higher than before clamping. Conclusions: Although hepatic parenchymal cell function was maintained after ischemia-reperfusion during hepatectomy, sinusoidal endothelial cell dysfunction was found. Release of granulocyte colony-stimulating factor and macrophage colony-stimulating factor after ischemia-reperfusion were also found. These cytokines and hyaluronic acid may be useful indicators in the early phase of human ischemia-reperfusion injury during hepatectomy.

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Documento generato il 29/03/20 alle ore 09:14:14