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Titolo:
Increased risk for ischaemic events is related to combined RAS polymorphism
Autore:
van Geel, PP; Pinto, YM; Zwinderman, AH; Henning, RH; van Boven, A; Jukema, JW; Bruschke, AVG; Kastelein, JJP; van Gilst, WH;
Indirizzi:
Univ Groningen, Dept Cardiol, NL-9713 AV Groningen, Netherlands Univ Groningen Groningen Netherlands NL-9713 AV V Groningen, Netherlands Univ Groningen Hosp, Dept Clin Pharmacol, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands macol, Groningen, Netherlands Leiden Univ, Dept Med Stat, NL-2300 RA Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RA NL-2300 RA Leiden, Netherlands Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands Leiden Univ Leiden Netherlands d Ctr, Dept Cardiol, Leiden, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands
Titolo Testata:
HEART
fascicolo: 4, volume: 85, anno: 2001,
pagine: 458 - 462
SICI:
1355-6037(200104)85:4<458:IRFIEI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING-ENZYME; II TYPE-1 RECEPTOR; CORONARY-ARTERY DISEASE; INSERTION DELETION POLYMORPHISM; A1166C GENE POLYMORPHISM; MYOCARDIAL-INFARCTION; EXPRESSION; ACE; ATHEROSCLEROSIS; PROGRESSION;
Keywords:
renin-angiotensin system; polymorphism; coronary atherosclerosis; ischaemic events;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: van Geel, PP Univ Groningen, Dept Cardiol, Antonius Deusinglaan 1, NL-9713AV Groningen, Netherlands Univ Groningen Antonius Deusinglaan 1 GroningenNetherlands NL-9713 AV
Citazione:
P.P. van Geel et al., "Increased risk for ischaemic events is related to combined RAS polymorphism", HEART, 85(4), 2001, pp. 458-462

Abstract

Objective-To determine whether the angiotensin converting enzyme (ACE) andthe angiotensin II type 1 receptor (AT(1)R A1166C) gene polymorphism interact to increase the risk of ischaemic events, and whether this can be explained by the progression of angiographically defined coronary atherosclerosis. Design-Prospective defined substudy of the lipid lowering regression trial(REGRESS). Setting-University hospital. Patients-885 male patients with stable coronary artery disease. Main outcome measures-Incidence of ischaemic events during a two year follow up; serial quantitative coronary arteriography (mean segment diameter and minimum obstruction diameter) at baseline and after two years. Results-Patients who carried both the ACE-DD and AT,R-CC genotype had significantly more ischaemic events during the two year follow up than those carrying other genotype combinations (p = 0.035, Mantel-Haenszel test for linear association). There was no association between the two genotypes and mean segment diameter or minimum obstruction diameter at baseline or after two years. Conclusions-The suggestion that ACE-DD and AT,R-CC genotypes interact to increase the risk of ischaemic events is confirmed. However, this increased risk was not accompanied by increased progression of angiographically defined coronary atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 07:42:50