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Titolo:
Serum interleukin-10 levels are an independent prognostic factor for patients with Hodgkin's lymphoma
Autore:
Vassilakopoulos, TP; Nadali, G; Angelopoulou, MK; Siakantaris, MP; Dimopoulou, MN; Kontopidou, FN; Rassidakis, GZ; Doussis-Anagnostopoulou, IA; Hatzioannou, M; Vaiopoulos, G; Kittas, C; Sarris, AH; Pizzolo, G; Pangalis, GA;
Indirizzi:
Natl & Kapodistrian Univ Athens, Sch Med, Laikon Gen Hosp, Dept Internal Med 1,Hematol Sect, Athens 11510, Greece Natl & Kapodistrian Univ Athens Athens Greece 11510 Athens 11510, Greece Univ Verona, Dept Clin & Expt Med, Sect Hematol, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 ed, Sect Hematol, I-37100 Verona, Italy Natl & Kapodistrian Univ Athens, Dept Histol Embryol, Athens 11510, GreeceNatl & Kapodistrian Univ Athens Athens Greece 11510 Athens 11510, Greece Univ Texas, MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030USA Univ Texas Houston TX USA 77030 pt Lymphoma Myeloma, Houston, TX 77030USA
Titolo Testata:
HAEMATOLOGICA
fascicolo: 3, volume: 86, anno: 2001,
pagine: 274 - 281
SICI:
0390-6078(200103)86:3<274:SILAAI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOKINE LEVELS CORRELATE; TUMOR-NECROSIS-FACTOR; APOPTOTIC CELL-DEATH; COMBINATION CHEMOTHERAPY; CANCER-INSTITUTE; T-CELLS; DISEASE; MOPP; ABVD; STAGE;
Keywords:
interleukin-10; serum levels; Hodgkin's lymphoma; prognostic factors; chemotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Pangalis, GA Natl & Kapodistrian Univ Athens, Sch Med, Laikon Gen Hosp, Dept Internal Med 1,Hematol Sect, 16 Sevastoupoleos Str,POB 14044, Athens 11510, Greece Natl & Kapodistrian Univ Athens 16 Sevastoupoleos Str,POB 14044 Athens Greece 11510
Citazione:
T.P. Vassilakopoulos et al., "Serum interleukin-10 levels are an independent prognostic factor for patients with Hodgkin's lymphoma", HAEMATOLOG, 86(3), 2001, pp. 274-281

Abstract

Background and Objectives, Interleukin-10 (IL-10) is a pleiotropic cytokine which increases bcl-2 levels and protects cells from steroid or doxorubicin-induced apoptosis. Hodgkin and Reed-Sternberg (HRS) cells bear functional IL-10 receptors, Thus serum IL-10 (sIL-10) might inhibit apoptosis in HRScells, which could occur as a result of either chemotherapy or the crippled immunoglobulin genes. Design and Methods. We determined sIL-10 levels in 122 patients with Hodgkin's lymphoma (HL), treated with ABVD or equivalent regimens with or without radiotherapy, and correlated them with presenting clinical and laboratoryfeatures, as well as failure-free survival (FFS) and overall survival. Results. Elevated sIL-10 revels (greater than or equal to 10pg/mL) were detected in 55 patients (45%), and were correlated with advanced stage and elevated serum beta (2)-microglobulin levels. At 7 years FFS was 85% vs. 63% for patients with normal vs, elevated sIL-10 levels, respectively (p=0.01);overall survival was 97% vs. 73% (p=0.005), Multivariate analysis with Cox's proportional hazards model demonstrated that elevated sIL-10 levels werethe strongest independent predictor of FFS, and were also associated with inferior overall survival. Interpretation and Conclusions. We conclude that sIL-10 revels are elevated in 45% of patients with HL, and are associated with inferior FFS and overall survival, independently of other established prognostic factors. (C) 2001, Ferrata Storti Foundation.

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Documento generato il 06/04/20 alle ore 06:58:58