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Titolo:
Identification of a new multigene four-transmembrane family (MS4A) relatedto CD20, HTm4 and beta subunit of the high-affinity IgE receptor
Autore:
Ishibashi, K; Suzuki, M; Sasaki, S; Imai, M;
Indirizzi:
Jichi Med Sch, Dept Pharmacol, Kawachi, Tochigi 3290498, Japan Jichi Med Sch Kawachi Tochigi Japan 3290498 wachi, Tochigi 3290498, Japan Tokyo Med & Dent Univ, Dept Internal Med 2, Tokyo 113, Japan Tokyo Med & Dent Univ Tokyo Japan 113 t Internal Med 2, Tokyo 113, Japan
Titolo Testata:
GENE
fascicolo: 1, volume: 264, anno: 2001,
pagine: 87 - 93
SICI:
0378-1119(20010207)264:1<87:IOANMF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOGLOBULIN-E RECEPTOR; BALB/C 3T3 CELLS; FC-EPSILON-RI; B DIFFERENTIATION ANTIGEN; GROWTH-FACTOR-I; EXPRESSION; GENE; LYMPHOCYTES; PROGRESSION; PROTEIN;
Keywords:
B-cell specific antigen; Fc epsilon RI beta; ion channel; lymphoid tissues; membrane protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Ishibashi, K Jichi Med Sch, Dept Pharmacol, Kawachi, Tochigi 3290498, Japan Jichi Med Sch Kawachi Tochigi Japan 3290498 i 3290498, Japan
Citazione:
K. Ishibashi et al., "Identification of a new multigene four-transmembrane family (MS4A) relatedto CD20, HTm4 and beta subunit of the high-affinity IgE receptor", GENE, 264(1), 2001, pp. 87-93

Abstract

We report here the cloning of eight new cDNAs that encode a family of proteins related to the B-cell-specific antigen CD20, a hematopoietic-cell-specific protein HTm4, and high affinity IgE receptor beta chain (Fc epsilon RIbeta). They include four clones from human, and another four clones from mouse. They share similar structure (four transmembrane domains) with amino acid identities of 25-40%. Therefore, they represent distinct genes and comprise a gene superfamily. This superfamily is now named membrane-spanning four-domains, subfamily A (the approved symbol is MS4A) to distinguish them from tetraspanins with similar structure. The highest homologies among these proteins are found in the transmembrane domains, especially in the first and second transmembrane domains, and conserved residues are also recognized in the inter-transmembrane domains. In northern blot, they were mostly expressed in lymphoid tissues: thymus and spleen. However, some were expressed in nonlymphoid tissues including brain, heart, kidney, liver, testis, lung, GI tracts, and pancreas. They may represent proteins functioning either directly as ligand-gated ion channels or as essential components of such channels. The identification of this relatively large gene family in various tissues will allow the further elucidation of physiological significance ofthis gene family, that is currently unclear, (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:38:43