Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Gene delivery and gene therapy with herpes simplex virus-based vectors
Autore:
Latchman, DS;
Indirizzi:
Univ Coll London, Inst Child Hlth, London WC1N 1EH, England Univ Coll London London England WC1N 1EH Hlth, London WC1N 1EH, England
Titolo Testata:
GENE
fascicolo: 1, volume: 264, anno: 2001,
pagine: 1 - 9
SICI:
0378-1119(20010207)264:1<1:GDAGTW>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPRESSING TYROSINE-HYDROXYLASE; NEUROTROPHIC FACTOR GDNF; GTP-CYCLOHYDROLASE-I; PARKINSONS-DISEASE; BETA-GALACTOSIDASE; NEURONAL CELLS; RAT MODEL; PRIMARY FIBROBLASTS; LATENT INFECTION; NERVOUS-SYSTEM;
Keywords:
gene delivery; gene therapy; virus vectors; Herpes simplex virus; neurological disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Latchman, DS Univ Coll London, Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England Univ Coll London 30 Guilford St London England WC1N 1EH land
Citazione:
D.S. Latchman, "Gene delivery and gene therapy with herpes simplex virus-based vectors", GENE, 264(1), 2001, pp. 1-9

Abstract

The development of efficient means of delivery genes in vivo is essential both for resting gene function in the intact animal and for human gene therapy procedures. A number of viral and non-viral gene delivery methods have been developed for this purpose. OF those herpes simplex virus (HSV)-based vectors have particular advantages for gene delivery to the nervous system including their ability to infect nondividing neurones and establish asymptomatic latent infections. Moreover, considerable progress has been made, firstly, in disabling HSV vectors so ns to prevent thr damaging effects of wild type virus and secondly, to ensure long-term expression of the inserted transgene(s). These vectors thus offer a valuable tool for testing gene function in neuronal cells in vivo and may ultimately be safe enough for use in human gene therapy procedures. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:26:32