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Titolo:
Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K+ channel and control regulation of RGS7 by G beta 5
Autore:
Keren-Raifman, T; Bera, AK; Zveig, D; Peleg, S; Witherow, DS; Slepak, VZ; Dascal, N;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 rmacol, IL-69978 Tel Aviv, Israel Univ Miami, Sch Med, Dept Mol & Cellular Pharmacol, Miami, FL 33101 USA Univ Miami Miami FL USA 33101 l & Cellular Pharmacol, Miami, FL 33101 USA Univ Miami, Sch Med, Program Neurosci, Miami, FL 33101 USA Univ Miami Miami FL USA 33101 Med, Program Neurosci, Miami, FL 33101 USA
Titolo Testata:
FEBS LETTERS
fascicolo: 1-2, volume: 492, anno: 2001,
pagine: 20 - 28
SICI:
0014-5793(20010309)492:1-2<20:ELORAR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-SUBUNIT; XENOPUS-OOCYTES; BETA-SUBUNIT; MEDIATED MODULATION; IN-VITRO; DOMAIN; COMPLEX; BINDING; STOICHIOMETRY; TRANSDUCIN;
Keywords:
G protein; regulator of G protein signaling; G protein-activated K+ channel; potassium channel; G beta 5; Xenopus oocyte;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Keren-Raifman, T Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol,IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 Tel Aviv, Israel
Citazione:
T. Keren-Raifman et al., "Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K+ channel and control regulation of RGS7 by G beta 5", FEBS LETTER, 492(1-2), 2001, pp. 20-28

Abstract

Regulators of G protein signaling RGS4 and RGS7 accelerate the kinetics ofK+ channels (GIRKs) in the Xenopus oocyte system. Here, via quantitative analysis of RGS expression, we reveal biphasic effects of RGSs on GIRK regulation, At low concentrations, RGS4 inhibited basal GIRK activity, but stimulated it at high concentrations. RGS7, which is associated with the G protein subunit G beta5, is regulated by G beta5 by two distinct mechanisms. First, G beta5 augments RGS7 activity. and second, it increases its expression. These dual effects resolve previous controversies regarding RGS4 and RGS7function and indicate that they modulate signaling by mechanisms supplementary to their GTPase-activating protein activity, (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 03:01:50