Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The many faces of the tumor suppressor gene APC
Autore:
van Es, JH; Giles, RH; Clevers, HC;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Immunol, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Univ Utrecht, Med Ctr, Ctr Biomed Genet, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands
Titolo Testata:
EXPERIMENTAL CELL RESEARCH
fascicolo: 1, volume: 264, anno: 2001,
pagine: 126 - 134
SICI:
0014-4827(20010310)264:1<126:TMFOTT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOMATOUS POLYPOSIS-COLI; BETA-CATENIN MUTATIONS; WINGLESS SIGNALING PATHWAYS; PROTEIN PHOSPHATASE 2A; COLORECTAL-CANCER; AXIS FORMATION; HEPATOCELLULAR CARCINOMAS; FUNCTIONAL INTERACTION; XENOPUS DEVELOPMENT; NEGATIVE REGULATOR;
Keywords:
APC; APC2; adenomatous polyposis coli; tumor suppressor gene; cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: van Es, JH Univ Utrecht, Med Ctr, Dept Immunol, POB 85500, NL-3508 GA Utrecht, Netherlands Univ Utrecht POB 85500 Utrecht Netherlands NL-3508 GA herlands
Citazione:
J.H. van Es et al., "The many faces of the tumor suppressor gene APC", EXP CELL RE, 264(1), 2001, pp. 126-134

Abstract

Inactivation of the tumor suppressor adenomatous polyposis coli (APC) protein is a critical early step in the development of familial and sporadic colon cancer. Close examination of the function of APC has shown that it is amultifunctional protein involved in a wide variety of processes, includingregulation of cell proliferation, cell migration, cell adhesion, cytoskeletal reorganization, and chromosomal stability. Tantalizing clues to the different functions of APC have been provided by the identification of proteins interacting with several discrete motifs within APC. Each of these putative functions could link APC inactivation with tumorigenesis. Here, we will summarize recent findings regarding the diverse role of APC. We will emphasize the interaction of APC with different binding partners, the role of these complex interactions for normal functioning of the cell, and how disruption of these interactions may play a role in tumor development. The rapid progress made recently shows the many faces of APC, leading to a constant reappreciation of this multitasking tumor suppressor protein. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:40:02