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Titolo:
Insulin resistance: Cellular and clinical concepts
Autore:
Cefalu, WT;
Indirizzi:
Univ Vermont, Coll Med, Dept Med, Endocrine Unit, Burlington, VT 05405 USAUniv Vermont Burlington VT USA 05405 crine Unit, Burlington, VT 05405 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 1, volume: 226, anno: 2001,
pagine: 13 - 26
SICI:
1535-3702(200101)226:1<13:IRCACC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-B; GLYCOGEN-SYNTHASE KINASE-3; CORONARY HEART-DISEASE; DEPENDENT DIABETES-MELLITUS; RAT SKELETAL-MUSCLE; PHOSPHATIDYLINOSITOL 3-KINASE ACTIVATION; HOMEOSTASIS MODEL ASSESSMENT; RECEPTOR SUBSTRATE FAMILY; AMINO-ACID-TRANSPORT; GLUCOSE-TRANSPORT;
Keywords:
insulin; type 2 diabetes; atherosclerosis; insulin resistance; metabolic syndrome;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
114
Recensione:
Indirizzi per estratti:
Indirizzo: Cefalu, WT Univ Vermont, Coll Med, Dept Med, Endocrine Unit, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 Burlington, VT 05405 USA
Citazione:
W.T. Cefalu, "Insulin resistance: Cellular and clinical concepts", EXP BIOL ME, 226(1), 2001, pp. 13-26

Abstract

Insulin resistance is defined as a clinical state in which a normal or elevated insulin level produces an attenuated biologic response. Specifically,the biologic response most studied is insulin-stimulated glucose disposal,yet the precise cellular mechanism responsible is not yet known. However, the presence of insulin resistance is observed many years before the onset of clinical hyperglycemia and the diagnosis of Type 2 diabetes. Insulin resistance at this stage appears to be significantly associated with a clustering of cardiovascular risk factors predisposing the individual to accelerated cardiovascular disease. An overview of insulin resistance and the associated clinical insulin resistant state will be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:45:22