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Titolo:
Sentinel node in breast cancer - a Swedish pilot study of 75 patients
Autore:
Frisell, J; Bergqvist, L; Liljegren, G; Thorn, M; Damm, S; Rydman, H; Danielsson, R;
Indirizzi:
Orebro Hosp, Dept Surg, Orebro, Sweden Orebro Hosp Orebro SwedenOrebro Hosp, Dept Surg, Orebro, Sweden Vasteras Hosp, Dept Surg, Vasteras, Sweden Vasteras Hosp Vasteras Sweden asteras Hosp, Dept Surg, Vasteras, Sweden Uppsala Hosp, Dept Surg, Uppsala, Sweden Uppsala Hosp Uppsala SwedenUppsala Hosp, Dept Surg, Uppsala, Sweden Huddinge Hosp, Dept Surg, S-14186 Huddinge, Sweden Huddinge Hosp Huddinge Sweden S-14186 ept Surg, S-14186 Huddinge, Sweden Huddinge Hosp, Dept Nucl Med, S-14186 Huddinge, Sweden Huddinge Hosp Huddinge Sweden S-14186 Nucl Med, S-14186 Huddinge, Sweden Orebro Hosp, Dept Nucl Med, Orebro, Sweden Orebro Hosp Orebro SwedenOrebro Hosp, Dept Nucl Med, Orebro, Sweden Vasteras Hosp, Dept Nucl Med, Vasteras, Sweden Vasteras Hosp Vasteras Sweden ras Hosp, Dept Nucl Med, Vasteras, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF SURGERY
fascicolo: 3, volume: 167, anno: 2001,
pagine: 179 - 183
SICI:
1102-4151(200103)167:3<179:SNIBC->2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPH-NODE; AXILLARY DISSECTION; RANDOMIZED TRIAL; CARCINOMA; BIOPSY; METASTASES; VALIDATION; MORBIDITY; RESECTION; STAGE;
Keywords:
sentinel node biopsy; breast cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Frisell, J Huddinge Univ Hosp, Karolinska Inst, Dept Surg, K 53, SE-14186 Stockholm, Sweden Huddinge Univ Hosp K 53 Stockholm Sweden SE-14186 holm, Sweden
Citazione:
J. Frisell et al., "Sentinel node in breast cancer - a Swedish pilot study of 75 patients", EURO J SURG, 167(3), 2001, pp. 179-183

Abstract

Objective: To find out if the sentinel node can be detected in sufficient numbers of women with breast cancer to be useful as a prognostic sign, whether it reflects that state of the entire axilla, and whether it detects micrometastases that would otherwise be missed. Design: Prospective study. Setting: 3 teaching hospitals, Sweden. Subjects: 75 patients with breast cancer who were Listed to have axillary dissection as well as resection of their tumour. Interventions: Injection of Tc-99 nanocolloid 0.4 mi and patent blue dye 1mi around the tumour or under the skin above the tumour, followed by preoperative lymphoscintigraphy and then identification of the sentinel node during operation either because it had turned blue or with a gamma probe. Removal of the sentinel node and complete axillary dissection. Main outcome measures: Identification of the sentinel node and presence ofmetastatic nodes in the axilla. Results: The sentinel node was identified in 69/75 (92%). It correctly predicted the state of the axilla in 66/69 (96%), and detected metastases in 24 of the 27 with invaded nodes in the axilla (89%). The false negative ratewas 11%. In 14/27 with axillary metastases (52%) the sentinel node was theonly involved node. In 3/24, metastases were detected by immunohistochemistry alone. Conclusion: Biopsy of the sentinel node predicted the presence or absence of axillary metastases with acceptable accuracy. However, before axillary node dissection is rejected in favour of sentinel node biopsy alone, large multicentre studies are needed to establish the true false negative rate.

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Documento generato il 12/07/20 alle ore 09:29:48