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Titolo:
Long-term biochemical results after operative treatment of primary hyperparathyroidism associated with multiple endocrine neoplasia types I and IIa: Is a more or less extended operation essential?
Autore:
Dotzenrath, C; Cupisti, K; Goretzki, PE; Yang, Q; Simon, D; Ohmann, C; Roher, HD;
Indirizzi:
Univ Dusseldorf, Dept Surg, DE-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany DE-40225 DE-40225 Dusseldorf, Germany Univ Dusseldorf, Unit Theoret Surg, DE-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany DE-40225 DE-40225 Dusseldorf, Germany
Titolo Testata:
EUROPEAN JOURNAL OF SURGERY
fascicolo: 3, volume: 167, anno: 2001,
pagine: 173 - 178
SICI:
1102-4151(200103)167:3<173:LBRAOT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL PARATHYROIDECTOMY; AUTO-TRANSPLANTATION; SURGICAL-MANAGEMENT; GLAND DISEASE; FOLLOW-UP; SURGERY; 2A;
Keywords:
primary hyperparathyroidism; multiple endocrine neoplasia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Dotzenrath, C Univ Dusseldorf, Dept Surg, Moorenstr 5, DE-40225 Dusseldorf, Germany Univ Dusseldorf Moorenstr 5 Dusseldorf Germany DE-40225 any
Citazione:
C. Dotzenrath et al., "Long-term biochemical results after operative treatment of primary hyperparathyroidism associated with multiple endocrine neoplasia types I and IIa: Is a more or less extended operation essential?", EURO J SURG, 167(3), 2001, pp. 173-178

Abstract

Objective: To analyse our long term results in patients operated on for primary hyperparathyroidism associated with multiple endocrine neoplasia types I and IIa. Design: Retrospective (data collection) and prospective (follow-up) analysis. Setting: University hospital, Germany. Subjects: 39 patients with MEN type I-associated and 7 patients with MEN-type-IIa-associated primary hyperparathyroidism. Interventions: Subtotal parathyroidectomy (n=25 with MEN I and 1 with MEN IIa), total parathyroidectomy and autotransplantation (one in each group) and removal of only enlarged glands (13 with MEN type I and 5 with MEN type IIa). Main outcome measurements: Recurrence rate of hyperparathyroidism andpermanent hypocalcaemia postoperatively. Results: Subtotal parathyroidectomy in patients with MEN type I gave a significantly lower recurrence rate than removal of only enlarged glands (3/25compared with 3/13, log rank, p = 0.04). Permanent hypocalcaemia developedin 3/25 compared with 3/13, respectively. 2/5 patients with MEN type IIa developed recurrences after removal of only enlarged glands and the rate washigher than expected. Conclusions: A more extensive operation is essential for patients with MENtype I; the rate of permanent hypocalcaemia is not increased, but the recurrence rate is reduced. Patients with MEN type IIa should be treated by excision of enlarged glands alone, but this may be extended to subtotal parathyroidectomy in patients with severe symptoms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:19:29