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Titolo:
Monoamine oxidase in developing rat renal cortex: effect of dexamethasone treatment
Autore:
Bompart, G; Copin, N; Djouadi, F; Bastin, J; Ordener, C; Parini, A;
Indirizzi:
CHU Rangueil, INSERM, U388, F-31403 Toulouse 4, France CHU Rangueil Toulouse France 4 INSERM, U388, F-31403 Toulouse 4, France Univ Paris 07, INSERM, U319, F-75251 Paris, France Univ Paris 07 Paris France F-75251 , INSERM, U319, F-75251 Paris, France
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 415, anno: 2001,
pagine: 19 - 26
SICI:
0014-2999(20010309)415:1<19:MOIDRR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-SKIN FIBROBLASTS; POSTNATAL-DEVELOPMENT; PERIPHERAL ORGANS; MESANGIAL CELLS; MAO-A; BRAIN; GLUCOCORTICOIDS; EXPRESSION; DOPAMINE; ESTROGEN;
Keywords:
monoamine oxidase; dexamethasone; renal cortex; development; (rat);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Parini, A CHU Rangueil, INSERM, U388, F-31054 Toulouse, France CHU Rangueil Toulouse France F-31054 F-31054 Toulouse, France
Citazione:
G. Bompart et al., "Monoamine oxidase in developing rat renal cortex: effect of dexamethasone treatment", EUR J PHARM, 415(1), 2001, pp. 19-26

Abstract

The expression of the biogenic amine degrading enzyme monoamine oxidases-Aand -B depends on several factors including regional distribution, development and hormonal environment. In the present study. we investigated the expression of monoamine oxidases in developing kidney and their regulation bydexamethasone treatment. Immunoblots and enzyme assays, performed using [C-14]S-hydroxytriptamine and C-14]beta -phenylethylamine as substrates for monoamine oxidases-A and -B, respectively, showed that monoamine oxidase-A is the isoenzyme largely predominant in 9-day-old rats renal cortex. Experiments performed in 5-week-old rats showed an increase in monoamine oxidase-Bactivity and a decrease in monoamine oxidase-A activity and substrate affinity. The changes of monoamine oxidase-A activity and affinity were mimicked by dexamethasone treatment (0.60 mg/kg body weight injected subcutaneously three times at intervals of 24 h) of 9-day-old rats. In contrast, dexamethasone administration induced a modification of monoamine oxidase-B activity opposite to that found between 9-day- and 5-week-old rats. Dexamethasone treatment did not modify immunoreactivity and mRNA corresponding to monoamine oxidases-A and -B indicating that changes of enzyme activities were unrelated to regulation of protein synthesis and mRNA turnover. These results show that monoamine oxidases-A and -B are differently expressed in developing renal cortex and are regulated by dexamethasone treatment. (C) 2001 Published by Elsevier Science B.V.

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Documento generato il 29/09/20 alle ore 22:10:09