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Titolo:
Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport (vol 12, pg 13, 2000)
Autore:
Hooiveld, GJEJ; van Montfoort, JE; Meijer, DKF; Muller, M;
Indirizzi:
Univ Groningen, Inst Drug Explorat, Div Gastroenterol & Hepatol, Groningen, Netherlands Univ Groningen Groningen Netherlands & Hepatol, Groningen, Netherlands Univ Groningen, Inst Drug Explorat, Dept Pharmacokinet & Drug Delivery, Groningen, Netherlands Univ Groningen Groningen Netherlands g Delivery, Groningen, Netherlands Univ Zurich Hosp, Div Clin Pharmacol & Toxicol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
fascicolo: 4, volume: 12, anno: 2001,
pagine: 523 -
SICI:
0928-0987(200102)12:4<523:FAROAC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIC ANION-TRANSPORTER; MULTIDRUG-RESISTANCE PROTEIN; GAMMA-GLUTAMYLCYSTEINE SYNTHETASE; DUBIN-JOHNSON-SYNDROME; FAMILIAL INTRAHEPATIC CHOLESTASIS; SALT EXPORT PUMP; MRP/GS-X PUMP; CMRP/CMOAT GENE-EXPRESSION; RAT HEPATOCYTE CULTURES; NECROSIS-FACTOR-ALPHA;
Tipo documento:
Correction, Addition
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
193
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, M Univ Groningen, Inst Drug Explorat, Div Gastroenterol & Hepatol,Groningen, Netherlands Univ Groningen Groningen Netherlands , Groningen, Netherlands
Citazione:
G.J.E.J. Hooiveld et al., "Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport (vol 12, pg 13, 2000)", EUR J PH SC, 12(4), 2001, pp. 523

Abstract

Hepatobiliary transport of endogenous and exogenous compounds is mediated by the coordinated action of multiple transport systems present at the sinusoidal (basolateral) and canalicular (apical) membrane domains of hepatocytes. During the last few years many of these transporters have been cloned and functionally characterized. In addition, the molecular bases of several forms of cholestatic liver disease have been defined. Combined, this has greatly expanded our understanding of the normal physiology of bile formation, the pathophysiology of intrahepatic cholestasis, as well as of drug elimination and disposition processes. In this review recent advances, with respect to function and regulation of ATP binding cassette transport proteins expressed in Liver, are summarized and discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:41:40