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Titolo:
Worsening of heart failure during hospital course of an unselected cohort of 2507 patients with myocardial infarction is a factor of poor prognosis: the PRIMA study
Autore:
de Gevigney, G; Ecochard, R; Rabilloud, M; Gaillard, S; Cheneau, E; Ducreux, C; Cao, D; Milon, H; Delahaye, F;
Indirizzi:
Hop Cardiovasc & Pneumol Louis Pradel, F-69394 Lyon 03, France Hop Cardiovasc & Pneumol Louis Pradel Lyon France 03 394 Lyon 03, France Hospices Civils Lyon, Dept Informat & Biostat Med, F-69424 Lyon, France Hospices Civils Lyon Lyon France F-69424 ostat Med, F-69424 Lyon, France Hop Croix Rousse, F-69317 Lyon 04, France Hop Croix Rousse Lyon France 04 op Croix Rousse, F-69317 Lyon 04, France
Titolo Testata:
EUROPEAN JOURNAL OF HEART FAILURE
fascicolo: 2, volume: 3, anno: 2001,
pagine: 233 - 241
SICI:
1388-9842(200103)3:2<233:WOHFDH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR EJECTION FRACTION; RISK STRATIFICATION; KILLIP CLASSIFICATION; CARDIOGENIC-SHOCK; FOLLOW-UP; MORTALITY; SURVIVAL; DEATH; AGE; WOMEN;
Keywords:
myocardial infarction; heart failure; worsening; in-hospital mortality; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: de Gevigney, G Hop Cardiovasc & Pneumol Louis Pradel, BP Lyon Montchat, F-69394 Lyon 03, France Hop Cardiovasc & Pneumol Louis Pradel BP Lyon Montchat Lyon France 03
Citazione:
G. de Gevigney et al., "Worsening of heart failure during hospital course of an unselected cohort of 2507 patients with myocardial infarction is a factor of poor prognosis: the PRIMA study", EUR J HE FA, 3(2), 2001, pp. 233-241

Abstract

Worsening of heart failure in patients with myocardial infarction is seldom studied, elderly patients often are not included, and multivariate analysis is uncommon. The prospective PRIMA study (Prise en charge de l'Infarctusdu Myocarde Aigu; management of acute myocardial infarction) sought to determine the incidence of worsening heart failure, its risk factors, and its prognostic importance in patients with myocardial infarction, regardless ofage and hospital facilities, in the 'real world' in a region in France, using multivariate analysis. Data were prospectively collected in all patients with myocardial infarction admitted in all hospitals in three departmentsin the Rhone-Alpes region in France between 1 September 1993 and 31 January 1995. Among the 2507 patients included, 33% were in Killip classes II-IV at admission. After exclusion of patients with admission Killip class IV, 416 patients (17% of the cohort, 24% of women and 14% of men) had worsening of Killip class during the first 5 days. In-hospital mortality (overall, 14%) increased dramatically with Killip class at admission (9% in class I, 62% in class IV) and with worsening of Killip class during the first 5 days (36.5 vs. 8.5% if no worsening). In multivariate analysis, older age, diabetes mellitus and anterior Q-wave myocardial infarction were significant predictors of Killip class at admission and of its worsening; Killip class >I at admission was a significant predictor of Killip-class worsening. The significant predictors of in-hospital mortality were older age, Killip class III at admission and worsening of Killip class during the first 5 days. This large, unselected cohort revealed that, among patients with myocardial infarction, heart failure and its worsening are frequent, especially in the elderly, and dramatically worsen the in-hospital mortality. (C) 2001 European Journal of Cardiology. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:39:47