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Titolo:
Neutrophil antiserum response to decrease in proteolytic activity in loaded rat muscle
Autore:
Morozov, VI; Usenko, TN; Rogozkin, VA;
Indirizzi:
Sci Res Inst Phys Culture, Dept Biochem, St Petersburg 197110, Russia Sci Res Inst Phys Culture St Petersburg Russia 197110 urg 197110, Russia Russian Acad Sci, Inst Cytol, Lab Mol Basis Cell Differentiat, St Petersburg 194064, Russia Russian Acad Sci St Petersburg Russia 194064 t Petersburg 194064, Russia
Titolo Testata:
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 84, anno: 2001,
pagine: 195 - 200
SICI:
1439-6319(200103)84:3<195:NARTDI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; ECCENTRIC EXERCISE; LEUKOCYTE INVASION; CREATINE-KINASE; INJURY; PROTEASES; SERUM; ACTIVATION; MECHANISMS; ISCHEMIA;
Keywords:
muscle; muscular activity; leukocytes; proteinases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Morozov, VI Sci Res Inst Phys Culture, Dept Biochem, Dynamo Ave 2, St Petersburg 197110, Russia Sci Res Inst Phys Culture Dynamo Ave 2 St PetersburgRussia 197110
Citazione:
V.I. Morozov et al., "Neutrophil antiserum response to decrease in proteolytic activity in loaded rat muscle", EUR J A PHY, 84(3), 2001, pp. 195-200

Abstract

The leukocytes that are found in skeletal muscles after intense muscular activity have been shown to infiltrate areas of injury in skeletal muscle tissue. We believe that leukocyte enzymes, which appear in the tissue after the degranulation or destruction of leukocytes, could play a role in tissue enzyme activities. Neutrophil proteinases were investigated, Histological data provided evidence of rat muscular tissue infiltration by leukocytes after intense physical loading. To reduce the influx of leukocytes in rat muscles, a rabbit antiserum against rat peritoneal leukocytes was injected intorats after muscle loading. This resulted in a reduction in muscle cytosol proteolytic activity as compared to control animals (who received saline injections), The levels of proteolytic activities of media conditioned by thesoleus muscle isolated from antiserum-treated rats were also reduced. These data provide evidence that the increase in proteolytic activity observed in rat skeletal muscles after physical loading is partially induced by neutrophil proteinases.

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Documento generato il 25/01/20 alle ore 16:13:47