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Titolo:
Infection of endothelial cells with Equine herpesvirus-1 (EHV-1) occurs where there is activation of putative adhesion molecules: a mechanism for transfer of virus
Autore:
Smith, DJ; Hamblin, AS; Edington, N;
Indirizzi:
Univ London Royal Vet Coll, London NW1 0TU, England Univ London Royal Vet Coll London England NW1 0TU ondon NW1 0TU, England
Titolo Testata:
EQUINE VETERINARY JOURNAL
fascicolo: 2, volume: 33, anno: 2001,
pagine: 138 - 142
SICI:
0425-1644(200103)33:2<138:IOECWE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR NECROSIS FACTOR; EXPRESSION; ABORTION; INTERLEUKIN-1; CHALLENGE; HORSES; MARES;
Keywords:
horse; Equine herpesvirus-1; activated endothelial cell molecules; pregnancy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Edington, N Univ London Royal Vet Coll, Royal Coll St, London NW1 0TU, England Univ London Royal Vet Coll Royal Coll St London England NW1 0TU
Citazione:
D.J. Smith et al., "Infection of endothelial cells with Equine herpesvirus-1 (EHV-1) occurs where there is activation of putative adhesion molecules: a mechanism for transfer of virus", EQUINE V J, 33(2), 2001, pp. 138-142

Abstract

Evidence is presented to show that activation of endothelial and leucoyte adhesion molecules is a key step in transferring virus from infected leucocytes; and determines the restricted tissue tropism. A range of tissues from2 experimentally infected mares in late pregnancy at 4 and 8 days after infection with EHV-1 were compared with those from normal pregnant and nonpregnant mares, Rabbit antisera to equine activated endothelial cell moleculeswere used to identify which tissues expressed these molecules in normal nongravid and gravid mares, and to investigate whether the range of tissues was altered in pregnant mares as a consequence of infection. The results indicated that the endothelium of the pregnant reproductive tract did express these molecules. In the 2 pregnant mares infected with EHV-1, the endothelial cells in the nasal mucosa also expressed these activated endothelial cell molecules. Therefore, the sites expressing these molecules closely correlated with those where virus infection of endothelial cells has been described and is consistent with experimental in vitro data, indicating that expression of these molecules is an essential stage in the transference of virusfrom leucocytes to endothelial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:31:13