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Titolo:
The effects of gabapentin on different ligand- and voltage-gated currents in isolated cortical neurons
Autore:
Stefani, A; Spadoni, F; Giacomini, P; Lavaroni, F; Bernardi, G;
Indirizzi:
Osped Santa Lucia, IRCCS, I-00179 Rome, Italy Osped Santa Lucia Rome Italy I-00179 a Lucia, IRCCS, I-00179 Rome, Italy Univ Roma Tor Vergata, Dip Neurosci, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 p Neurosci, I-00133 Rome, Italy Univ Rome La Sapienza, Neurol Clin, Rome, Italy Univ Rome La Sapienza Rome Italy La Sapienza, Neurol Clin, Rome, Italy
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 3, volume: 43, anno: 2001,
pagine: 239 - 248
SICI:
0920-1211(200103)43:3<239:TEOGOD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPROTECTIVE AGENT 619C89; ALPHA(2)DELTA SUBUNIT; CALCIUM CURRENTS; NEOCORTICAL NEURONS; CONTROLLED TRIAL; CHANNEL; INHIBITION; LAMOTRIGINE; MODULATION; EPILEPSY;
Keywords:
antiepileptic drugs; calcium currents; calcium-dependent potassium currents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Stefani, A Osped Santa Lucia, IRCCS, Via Ardeatina 306, I-00179 Rome, Italy Osped Santa Lucia Via Ardeatina 306 Rome Italy I-00179 , Italy
Citazione:
A. Stefani et al., "The effects of gabapentin on different ligand- and voltage-gated currents in isolated cortical neurons", EPILEPSY R, 43(3), 2001, pp. 239-248

Abstract

A clear picture of the mechanisms of action of the anti-epileptic agent gabapentin is far from being accomplished. We have analyzed the effects of gabapentin on ligand- and voltage-gated currents in isolated adult rat cortical neurons. Gabapentin failed to modify glutamate currents and produced a slight reduction of GABA responses. Negligible inhibition of sodium, but consistent inhibition of high-voltage-activated calcium conductance was promoted by gabapentin. In addition, gabapentin reduced calcium current sensitivity to dihydropyridine agonist and antagonists. Interestingly, gabapentin also decreased a not-inactivating. cadmium-sensitive, potassium current. These unconventional effects might underlie its efficacy in a variety of diseases which involve periodic discharge patterns as neuropathic pain or essential tremor. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:24:43