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Titolo:
Methods to identify and characterize developmental neurotoxicity for humanhealth risk assessment. II: Neuropathology
Autore:
Garman, RH; Fix, AS; Jortner, BS; Jensen, KF; Hardisty, JF; Claudio, L; Ferenc, S;
Indirizzi:
Vet Pathol Inc, Murrysville, PA USA Vet Pathol Inc Murrysville PA USAVet Pathol Inc, Murrysville, PA USA Procter & Gamble Co, Cincinnati, OH USA Procter & Gamble Co Cincinnati OHUSA er & Gamble Co, Cincinnati, OH USA Virginia Polytech Inst & State Univ, Coll Vet Med, Lab Neurotox Studies, Blacksburg, VA 24061 USA Virginia Polytech Inst & State Univ Blacksburg VA USA 24061 VA 24061 USA US EPA, Div Neurotoxicol, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 oxicol, Res Triangle Pk, NC 27711 USA Expt Pathol Labs Inc, Res Triangle Pk, NC USA Expt Pathol Labs Inc Res Triangle Pk NC USA Inc, Res Triangle Pk, NC USA Mt Sinai Sch Med, Div Environm & Occupat Med, New York, NY USA Mt Sinai Sch Med New York NY USA nvironm & Occupat Med, New York, NY USA Grocery Manufacturers Amer, Washington, DC USA Grocery Manufacturers AmerWashington DC USA rs Amer, Washington, DC USA
Titolo Testata:
ENVIRONMENTAL HEALTH PERSPECTIVES
, volume: 109, anno: 2001, supplemento:, 1
pagine: 93 - 100
SICI:
0091-6765(200103)109:<93:MTIACD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRILLARY ACIDIC PROTEIN; DEVELOPING RAT-BRAIN; NERVOUS-SYSTEM; NEONATAL RAT; APOPTOTIC NEURODEGENERATION; NEURONAL DEGENERATION; MORPHOMETRIC ANALYSIS; STEREOLOGICAL METHODS; CEREBRAL-CORTEX; ACUTE EXPOSURE;
Keywords:
brain development; fixation; histology; morphometry; neuropathology; neurotoxicity testing; peripheral neuropathy; special stains; stereology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Garman, RH ILSI Risk Sci Inst, 1126 16th St NW, Washington, DC 20036 USA ILSI Risk Sci Inst 1126 16th St NW Washington DC USA 20036 USA
Citazione:
R.H. Garman et al., "Methods to identify and characterize developmental neurotoxicity for humanhealth risk assessment. II: Neuropathology", ENVIR H PER, 109, 2001, pp. 93-100

Abstract

Neuropathologic assessment of chemically induced developmental alterationsin the nervous system for regulatory purposes is a multifactorial, complexprocess. This calls for careful qualitative and quantitative morphologic study of numerous brains at several developmental stages in rats. Quantitative evaluation may include such basic methods as determination of brain weight and dimensions as well as the progressively more complex approaches of linear, areal, or stereologic measurement of brain sections. Histologic evaluation employs routine stains (such as hematoxylin and eosin), which can becomplemented by a variety of special and immunohistochemical procedures. These brain studies are augmented by morphologic assessment of selected peripheral nervous system structures. Studies of this nature require a high level of technical skill as well as special training on the pari of the pathologist. The pathologist should have knowledge of normal microscopic neuroanatomy/neuronal circuitry and an understanding of basic principles of developmental neurobiology, such as familiarity with the patterns of physiologic or programmed cell death (apoptosis) expected at those developmental stages to be examined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:09:47