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Titolo:
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
Autore:
Tobiume, K; Matsuzawa, A; Takahashi, T; Nishitoh, H; Morita, K; Takeda, K; Minowa, O; Miyazono, K; Noda, T; Ichijo, H;
Indirizzi:
Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan Tokyo Med & Dent Univ Tokyo Japan 1138549 unkyo Ku, Tokyo 1138549, Japan Japanese Fdn Canc Res, Inst Canc, Dept Biochem, Tokyo 1708455, Japan Japanese Fdn Canc Res Tokyo Japan 1708455 Biochem, Tokyo 1708455, Japan Japanese Fdn Canc Res, Inst Canc, Dept Cell Biol, Tokyo 1708455, Japan Japanese Fdn Canc Res Tokyo Japan 1708455 ell Biol, Tokyo 1708455, Japan
Titolo Testata:
EMBO REPORTS
fascicolo: 3, volume: 2, anno: 2001,
pagine: 222 - 228
SICI:
1469-221X(200103)2:3<222:AIRFSA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR RECEPTOR; N-TERMINAL KINASE; CELL-DEATH; SIGNAL-TRANSDUCTION; FACTOR-ALPHA; 1 ASK1; FAS; MITOCHONDRIA; THIOREDOXIN; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Ichijo, H Tokyo Med & Dent Univ, Lab Cell Signaling, Grad Sch, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138549, Japan Tokyo Med & Dent Univ 1-5-45 Yushima Tokyo Japan 1138549 Japan
Citazione:
K. Tobiume et al., "ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis", EMBO REP, 2(3), 2001, pp. 222-228

Abstract

Apoptosis signal-regulating kinase (ASK) 1 is activated in response to various cytotoxic stresses including TNF, Fas and reactive oxygen species (ROS) such as H2O2 and activates c-Jun NH2-terminal kinase (JNK) and p38. However, the roles of JNK and p38 signaling pathways during apoptosis have been controversial. Here we show that by deleting ASK1 in mice, TNF- and H2O2-induced sustained activations of INK and p38 are lost in ASK1(-/-) embryonic fibroblasts, and that ASK1(-/-) cells are resistant to TNF- and H2O2-induced apoptosis. TNF- but not Fas-induced apoptosis requires ROS-dependent activation of ASK1-JNK/p38 pathways. Thus, ASK1 is selectively required for TNF- and oxidative stress-induced sustained activations of JNK/p38 and apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:11:02