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Titolo:
Effects of ethanol administration on hepatocellular ultrastructure of regenerating liver induced by partial hepatectomy
Autore:
Morales-Gonzalez, JA; Jimenez-Garcia, LF; Gutierrez-Salinas, J; Sepulveda, J; Leija-Salas, A; Hernandez-Munoz, H;
Indirizzi:
Natl Autonomous Univ Mexico, Inst Fisiol Celular, Dept Biol Celular, Mexico City 04510, DF, Mexico Natl Autonomous Univ Mexico Mexico City DF Mexico04510 04510, DF, Mexico Natl Autonomous Univ Mexico, Lab Microscopia Elect, Dept Biol, Fac Ciencias, Mexico City 04510, DF, Mexico Natl Autonomous Univ Mexico Mexico City DF Mexico 04510 04510, DF, Mexico Natl Autonomous Univ Mexico, Dept Ingn Metab, Mexico City 04510, DF, Mexico Natl Autonomous Univ Mexico Mexico City DF Mexico 04510 04510, DF, Mexico
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 2, volume: 46, anno: 2001,
pagine: 360 - 369
SICI:
0163-2116(200102)46:2<360:EOEAOH>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-LIVER; INHIBITION;
Keywords:
alcohol; nuclear activity; nucleolus; cell proliferation; ethanol metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hernandez-Munoz, H Natl Autonomous Univ Mexico, Inst Fisiol Celular, Dept Biol Celular, Apdo Postal 70-243, Mexico City 04510, DF, Mexico Natl Autonomous Univ Mexico Apdo Postal 70-243 Mexico City DF Mexico 04510
Citazione:
J.A. Morales-Gonzalez et al., "Effects of ethanol administration on hepatocellular ultrastructure of regenerating liver induced by partial hepatectomy", DIG DIS SCI, 46(2), 2001, pp. 360-369

Abstract

Acute ethanol administration partially inhibits DNA and protein syntheses during liver regeneration (LR) induced by partial hepatectomy (PH) in rats. Previous findings that the magnitude of ethanol's deleterious effects on LR are related to the route and timing of its administration led us to perform studies at the ultrastructural level, comparing ethanol effects on PH-induced LR, as a consequence of its administration route. PH promoted alterations on the endoplasmic reticulum and mitochondria, accompanied by decreased glycogen and increased lipid content in cytoplasm. Structural nuclear andnucleolar activities were also evident. Intragastric ethanol administration practically abolished the adaptative changes found in PH-promoted regenerating hepatocytes, whereas its administration through the intraperitoneal route induced later ultrastructural modifications, indicating cellular proliferation. These results suggest that ethanol, under certain conditions, could stimulate liver proliferation triggered by PH. The mechanism underlying this surprising effect of ethanol on LR remains to be elucidated, However, it is suggested that an altered ethanol metabolism by rats subjected to PH could be involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 05:36:06