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Titolo:
The role of Ultrabithorax in the patterning of adult thoracic muscles in Drosophila melanogaster
Autore:
Rivlin, PK; Gong, A; Schneiderman, AM; Booker, R;
Indirizzi:
Cornell Univ, Dept Neurobiol & Behav, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 Neurobiol & Behav, Ithaca, NY 14853 USA
Titolo Testata:
DEVELOPMENT GENES AND EVOLUTION
fascicolo: 2, volume: 211, anno: 2001,
pagine: 55 - 66
SICI:
0949-944X(200102)211:2<55:TROUIT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMEOTIC GENE-FUNCTION; BITHORAX-COMPLEX; WING DISK; FLIGHT-MUSCLE; EXPRESSION; MUTATIONS; DIFFERENTIATION; DIVERSIFICATION; TRANSCRIPTS; INNERVATION;
Keywords:
Drosophila; Ultrabithorax; homeotic; muscles; adult;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Rivlin, PK Cornell Univ, Dept Neurobiol & Behav, W121 Seeley G Mudd Hall, Ithaca, NY 14853 USA Cornell Univ W121 Seeley G Mudd Hall Ithaca NY USA 14853 53 USA
Citazione:
P.K. Rivlin et al., "The role of Ultrabithorax in the patterning of adult thoracic muscles in Drosophila melanogaster", DEV GENES E, 211(2), 2001, pp. 55-66

Abstract

Mutations in the homeotic gene, Ultrabithorax (Ubx), result in the transformation of the third thoracic (T3) segment into the second thoracic (T2) segment. Although it has been well established that these mutations have striking effects on adult epidermal structures in T3, the effect of these mutations on the adult musculature has been controversial. In this study, a series of Ubx regulatory mutations, anterobithorax, bithorax, postbithorax, andbithoraxoid, as well as combinations of these alleles were used to reevaluate the role of Ubx in the patterning of the T3 musculature. Homeotic indirect and direct flight muscles (IFMs and DFMs) were identified in the transformed T3 segment of all alleles and allelic combinations with the exceptionof postbithorax. We critically evaluated the pattern and amount of these muscles and found that while the amount and/or quality of homeotic IFMs increased, the amount of homeotic DFMs did not vary significantly as the severity of the ectodermal transformation increased. Because Ubx is not expressedin the adult mesoderm of T3, these results suggest that inductive cues play a major role in the patterning of adult thoracic muscles. We provide a model that illustrates the central role of inductive cues in generating the final adult muscle pattern in the thorax.

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Documento generato il 01/12/20 alle ore 07:05:36