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Titolo:
Alzheimer's disease and the cerebellum: A morphologic study on neuronal and glial changes
Autore:
Sjobeck, M; Englund, E;
Indirizzi:
Univ Lund Hosp, Dept Pathol & Cytol, Div Neuropathol, S-22185 Lund, SwedenUniv Lund Hosp Lund Sweden S-22185 Div Neuropathol, S-22185 Lund, Sweden
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 3, volume: 12, anno: 2001,
pagine: 211 - 218
SICI:
1420-8008(200105/06)12:3<211:ADATCA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PLAQUES; NUCLEUS BASALIS; DOWNS-SYNDROME; BRAIN-STEM; ATROPHY; VERMIS; DEGENERATION; PREVALENCE; MEYNERT;
Keywords:
Alzheimer's disease; cerebellum; Purkinje cells; neuronal counting; inferior olivary nucleus; gliosis; atrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Englund, E Univ Lund Hosp, Dept Pathol & Cytol, Div Neuropathol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 thol, S-22185 Lund, Sweden
Citazione:
M. Sjobeck e E. Englund, "Alzheimer's disease and the cerebellum: A morphologic study on neuronal and glial changes", DEMENT G C, 12(3), 2001, pp. 211-218

Abstract

Structural manifestations of Alzheimer's disease (AD) including neuronal loss were investigated in 12 cases of AD and in 10 healthy age-matched controls, with focus on the cerebellum. Linear Purkinje cell (PC) density was measured in the vermis and cerebellar hemispheres. Neurons were also counted in the inferior olivary nucleus. In vermis of the AD cases, the mean PC number was significantly lower (p = 0.019) than in the controls. The neurons in the inferior olive were similarly fewer, though not significantly (p = 0.13). Molecular layer gliosis and atrophy in the vermis was clearly severer in AD than in the controls. Features typical of cerebral Alzheimer encephalopathy (plaques, tangles and microvacuolization) were inconspicious. The structural cerebellar changes in the AD cases were thus neuronal loss, atrophy and gliosis, judged to represent the disease process, and with a main involvement in the vermis. This may be reflected in some of the symptoms and signs seen in AD, signs that are generally overlooked or judged to be of noncerebellar origin. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 23/01/20 alle ore 06:56:48