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Titolo:
Occipital glucose metabolism in dementia with Lewy bodies with and withoutparkinsonism: A study using positron emission tomography
Autore:
Imamura, T; Ishii, K; Hirono, N; Hashimoto, M; Tanimukai, S; Kazui, H; Hanihara, T; Sasaki, M; Mori, E;
Indirizzi:
Hyogo Inst Aging Brain & Cognit Disorders, Div Clin Neurosci, Himeji, Hyogo 670, Japan Hyogo Inst Aging Brain & Cognit Disorders Himeji Hyogo Japan 670 0, Japan Hyogo Inst Aging Brain & Cognit Disorders, Div Neuroimaging Res, Himeji, Hyogo 670, Japan Hyogo Inst Aging Brain & Cognit Disorders Himeji Hyogo Japan 670 0, Japan
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 3, volume: 12, anno: 2001,
pagine: 194 - 197
SICI:
1420-8008(200105/06)12:3<194:OGMIDW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; BODY DISEASE; CLINICAL-DIAGNOSIS; RELIABILITY; CONSORTIUM; VALIDITY; CRITERIA; REGISTRY; VARIANT; DLB;
Keywords:
dementia with Lewy bodies; Alzheimer's disease; Parkinson's disease; cerebral metabolism; occipital lobe; F-18-fluorodeoxyglucose; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Imamura, T Hyogo Inst Aging Brain & Cognit Disorders, Div Clin Neurosci, 520 Saisho Ko, Himeji, Hyogo 670, Japan Hyogo Inst Aging Brain & Cognit Disorders 520 Saisho Ko Himeji Hyogo Japan 670
Citazione:
T. Imamura et al., "Occipital glucose metabolism in dementia with Lewy bodies with and withoutparkinsonism: A study using positron emission tomography", DEMENT G C, 12(3), 2001, pp. 194-197

Abstract

Reduction of glucose metabolism in the occipital lobe is reported in dementia with Lewy bodies (DLB) and Parkinson's disease. If dysfunction of the nigrostriatal system is responsible for occipital hypometabolism, (1) DLB patients with parkinsonism would show a lower occipital metabolism than do patients without parkinsonism, and (2) DLB patients without parkinsonism would show an occipital metabolism comparable to those of normal subjects and patients with Alzheimer's disease (AD). To examine these hypotheses, we studied the regional cerebral metabolic rate of glucose (rCMRglc) in patients with a clinical diagnosis of DLB or AD, using F-18-fluorodeoxyglucose and positron emission tomography. The subjects consisted of 15 DLB patients with parkinsonism, 7 DLB patients without parkinsonism and 7 AD patients withoutparkinsonism. The medial and lateral occipital rCMRglc was significantly lower in the DLB patients without parkinsonism than in the AD patients. There were no significant differences in occipital metabolic rates be-tween theDLB groups with and without parkinsonism, DLB patients without parkinsonism showed a significant reduction of occipital glucose metabolism which is comparable with that of DLB patients with parkinsonism. The neurobiological bases of occipital hypometabolism in DLB may be pathological processes in the brainstem or basal forebrain structures other than the nigrostriatal system. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:16:04