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Titolo:
Mapping pathological Tc-99m-d,I-hexamethylpropylene amine oxime uptake in Alzheimer's disease and frontal lobe dementia with SPECT
Autore:
Pagani, M; Salmaso, D; Ramstrom, C; Jonsson, C; Lundqvist, R; Thurfjell, L; Schnell, PO; Wagner, A; Jacobsson, H; Larsson, SA;
Indirizzi:
Karolinska Hosp, Nucl Med Sect, Dept Neurol, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 ol, SE-17176 Stockholm, Sweden Karolinska Hosp, Nucl Med Sect, Dept Diagnost Radiol, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 ol, SE-17176 Stockholm, Sweden Lowenstromska Hosp, Dept Geriatr, Stockholm, Sweden Lowenstromska Hosp Stockholm Sweden sp, Dept Geriatr, Stockholm, Sweden Uppsala Univ, Ctr Image Anal, Uppsala, Sweden Uppsala Univ Uppsala Sweden psala Univ, Ctr Image Anal, Uppsala, Sweden CNR, Inst Neurobiol & Mol Med, Rome, Italy CNR Rome ItalyCNR, Inst Neurobiol & Mol Med, Rome, Italy CNR, Dept Psychol, Rome, Italy CNR Rome ItalyCNR, Dept Psychol, Rome, Italy
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 3, volume: 12, anno: 2001,
pagine: 177 - 184
SICI:
1420-8008(200105/06)12:3<177:MPTAOU>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; PHOTON-EMISSION TOMOGRAPHY; FRONTOTEMPORAL DEMENTIA; COMPUTED-TOMOGRAPHY; GLUCOSE-METABOLISM; CLINICAL-DIAGNOSIS; BASAL GANGLIA; REDUCTION; ABNORMALITIES; CEREBELLAR;
Keywords:
Alzheimer's disease; brain atlas; frontal lobe dementia; regional cerebral blood flow; single photon emission computed tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Pagani, M Karolinska Hosp, Nucl Med Sect, Dept Neurol, SE-17176 Stockholm,Sweden Karolinska Hosp Stockholm Sweden SE-17176 76 Stockholm, Sweden
Citazione:
M. Pagani et al., "Mapping pathological Tc-99m-d,I-hexamethylpropylene amine oxime uptake in Alzheimer's disease and frontal lobe dementia with SPECT", DEMENT G C, 12(3), 2001, pp. 177-184

Abstract

Seventeen patients with probable Alzheimer's disease (AD), 7 patients withfrontal lobe dementia (FLD) and 19 control subjects (NOR) were examined byTc-99m-d,l-hexamethylpropylene amine oxime (Tc-99m-HMPAO) SPECT. Images were standardised in the same 3D space and averaged within each group. After normalisation, the three sets of images were analysed in all cerebral lobes, hippocampus, thalamus and basal ganglia. In AD, the Tc-99m-HMPAO uptake values were significantly reduced, as compared to NOR, in the parietal, temporal and insular lobes. In patients with FLD, the uptake was altered in alllobes with the exception of the parietal lobe. The uptake in the nucleus caudatus decreased significantly in both AD and FLD as compared to NOR. The uptake in the anterior cingulate cortex was significantly reduced in FLD. Subtraction images highlighted all significantly decreased areas. In conclusion, standardising SPECT in a common space and subtracting data from a control group improves the visual interpretation of images. In this study, the typical temporo-parietal and fronto-parietal Tc-99m-HMPAO uptake reductionswere found in AD and FLD, respectively. The uptake in the nucleus caudatuswas found to decrease significantly in AD and FLD and the one in the anterior cingulate cortex was reduced in FLD. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 25/01/20 alle ore 16:00:11