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Titolo:
Sequence specific recognition of ligand-DNA complexes studied by NMR
Autore:
Han, XG; Gao, XL;
Indirizzi:
Univ Houston, Dept Chem, Houston, TX 77204 USA Univ Houston Houston TX USA 77204 uston, Dept Chem, Houston, TX 77204 USA
Titolo Testata:
CURRENT MEDICINAL CHEMISTRY
fascicolo: 5, volume: 8, anno: 2001,
pagine: 551 - 581
SICI:
0929-8673(200104)8:5<551:SSROLC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; MINOR-GROOVE-BINDING; INTERSTRAND CROSS-LINK; CENTER-DOT-T; RESTRAINED MOLECULAR-DYNAMICS; ANTITUMOR DRUG NOGALAMYCIN; COVALENT DUOCARMYCIN-A; ADDUCT OPPOSITE DC; BASE-PAIRS; STRUCTURAL BASIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
238
Recensione:
Indirizzi per estratti:
Indirizzo: Gao, XL Univ Houston, Dept Chem, Houston, TX 77204 USA Univ Houston Houston TX USA 77204 ept Chem, Houston, TX 77204 USA
Citazione:
X.G. Han e X.L. Gao, "Sequence specific recognition of ligand-DNA complexes studied by NMR", CURR MED CH, 8(5), 2001, pp. 551-581

Abstract

The last few years have represented an accelerated accumulation in detailed information about ligand-DNA interactions. A collected view of literatureinformation is essential for advancing our understanding of the principlesof ligand-DNA recognition, utilizing this valuable information for construction of a modeling database, and eventually the rational design of DNA-binding ligands possessing desired properties. This review is concentrated on structure-based information on ligand-oligodeoxyribonucleotide (DON) complexes published since 1995, especially focusing on the results obtained from NMR structure elucidation. The discussionsemphasize the sequence specific recognition of novel binding motifs or binding modules of ligand molecules rather than specific atomic details. A comprehensive list of DNA binding ligands are discussed in the text and are also summarized in a table. The DNA sequences that are recognized by specific ligand molecules as studied by NMR are annotated in a figure to provide a clear view of target selection. This review also briefly describes NMR methods for characterization and structure elucidation of ligand-DNA complexes.

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Documento generato il 27/10/20 alle ore 10:23:44