Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Control of gastric acid secretion: the gastrin-ECL cell-parietal cell axis
Autore:
Lindstrom, E; Chen, D; Norlen, P; Andersson, K; Hakanson, R;
Indirizzi:
Univ Lund, Dept Pharmacol, Inst Physiol Sci, Lund, Sweden Univ Lund LundSweden d, Dept Pharmacol, Inst Physiol Sci, Lund, Sweden
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 3, volume: 128, anno: 2001,
pagine: 505 - 514
SICI:
1095-6433(200103)128:3<505:COGAST>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTEROCHROMAFFIN-LIKE CELLS; ELECTRON-MICROSCOPIC IDENTIFICATION; CHOLECYSTOKININ-B/GASTRIN RECEPTOR; MESSENGER-RNA ABUNDANCE; RAT STOMACH; HISTIDINE-DECARBOXYLASE; ENDOCRINE-CELLS; ALPHA-FLUOROMETHYLHISTIDINE; AMINOPYRINE ACCUMULATION; HISTAMINE-RELEASE;
Keywords:
gastrin; ECL cells; histamine; histidine decarboxylase; acid secretion; parietal cells; neuropeptides; acetylcholine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Hakanson, R Univ Lund, Dept Pharmacol, Inst Physiol Sci, Solvegatan 10, Lund, Sweden Univ Lund Solvegatan 10 Lund Sweden vegatan 10, Lund, Sweden
Citazione:
E. Lindstrom et al., "Control of gastric acid secretion: the gastrin-ECL cell-parietal cell axis", COMP BIOC A, 128(3), 2001, pp. 505-514

Abstract

Gastric acid secretion is under nervous and hormonal control. Gastrin, themajor circulating stimulus of acid secretion, probably does not stimulate the parietal cells directly but acts to mobilize histamine from the ECL cells in the oxyntic mucosa. Histamine stimulates the parietal cells to secrete HCl. The gastrin-ECL cell pathway has been investigated extensively in situ (gastric submucosal microdialysis), in vitro (isolated ECL cells) and invivo (intact animals). Gastrin acts on CCK, receptors to control the synthesis of ECL-cell histamine, accelerating the expression of the histamine-forming enzyme histidine decarboxylase (HDC) at both the transcription and the translation/posttranslation levels. Depletion of histamine by alpha -fluoromethylhistidine (an irreversible inhibitor of HDC) prevents gastrin-induced but not histamine-induced gastric acid secretion. Acute CCK, receptor blockade inhibits gastrin-evoked but not histamine-induced acid secretion. Studies both in vivo/in situ and in vitro have suggested that while acetylcholine seems capable of activating parietal cells, it does not affect histamine secretion from ECL cells. Unlike acetylcholine, the neuropeptides pituitary adenylate cyclase-activating peptide and vasoactive intestinal peptide mobilize ECL-cell histamine. Whether vagally stimulated acid secretion reflects an effect of the enteric nervous system on the ECL cells (neuropeptides) and/or a direct one on the parietal cells needs to be further investigated. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:21:44