Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Familial aggregation of QT-interval variability in a general population: results from the NHLBI Family Heart Study
Autore:
Hong, Y; Rautaharju, PM; Hopkins, PN; Arnett, DK; Djousse, L; Pankow, JS; Sholinsky, P; Rao, DC; Province, MA;
Indirizzi:
Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Div Biostat, St Louis, MO 63110 USA Wake Forest Univ, Dept Publ Hlth, Winston Salem, NC 27109 USA Wake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA Univ Utah, Salt Lake City, UT USA Univ Utah Salt Lake City UT USAUniv Utah, Salt Lake City, UT USA Univ Minnesota, Dept Epidemiol, Minneapolis, MN USA Univ Minnesota Minneapolis MN USA a, Dept Epidemiol, Minneapolis, MN USA Boston Univ, Prevent Med & Epidemiol Sect, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 ed & Epidemiol Sect, Boston, MA 02215 USA Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA , Dept Epidemiol, Chapel Hill, NC USA NHLBI, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 & Clin Applicat, NIH, Bethesda, MD 20892 USA Washington Univ, Dept Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Genet, St Louis, MO 63110 USA Washington Univ, Dept Psychiat, St Louis, MO 63110 USA Washington Univ StLouis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA
Titolo Testata:
CLINICAL GENETICS
fascicolo: 3, volume: 59, anno: 2001,
pagine: 171 - 177
SICI:
0009-9163(200103)59:3<171:FAOQVI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX SEGREGATION ANALYSIS; POTASSIUM CHANNEL GENE; MOLECULAR-BASIS; CARDIOVASCULAR MORTALITY; VENTRICULAR ARRHYTHMIAS; CARDIAC-ARRHYTHMIA; SUDDEN-DEATH; RISK FACTOR; TWINS; PROLONGATION;
Keywords:
familial aggregation; genetic epidemilogy; heritability; QT interval; segregation analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Hong, Y Washington Univ, Sch Med, Div Biostat, Campus Box 8067,660 S Euclid Ave, St Louis, MO 63110 USA Washington Univ Campus Box 8067,660 S Euclid Ave St Louis MO USA 63110
Citazione:
Y. Hong et al., "Familial aggregation of QT-interval variability in a general population: results from the NHLBI Family Heart Study", CLIN GENET, 59(3), 2001, pp. 171-177

Abstract

QT-interval prolongation is associated with increased risk of cardiac death, Although information on genetics and molecular mechanisms of the congenital long QT syndrome is mounting, limited data are available on the genetics of QT interval in the general population. Heart rate adjusted QT intervals (Bazett's QTc, and QT index (QTI)) were assessed by electrocardiography in 2399 members aged 25-91 years of 468 randomly selected families participating in the NHLBI Family Heart Study, Familial correlation and segregation analyses were performed to evaluate the genetics of the variability of QT interval in this population. The parent-offspring (0.14 +/- 0.03) and sibling (0.18 +/- 0.03) correlations for age and sex-adjusted QTc were moderate, while the spouse correlation was close to zero (0.09 +/- 0.06). This suggests that there are familial/genetic influences on QT-interval variability. Segregation analysis results suggest that there is a major effect in addition to heritable multifactorial effects (h(2) = 0.34), but the major effect did not follow Mendelian inheritance. Further adjustments of QTc for other major cardiovascular risk factors did not significantly change the results, Similar results were found for QTI. The QT-interval variation in the general population is influenced by moderate heritable multifactorial effects in addition to a major effect. A majorgene effect is not directly supported.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:26:44