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Titolo:
Platelet and leukocyte deactivation after intracoronary stent placement inpatients receiving combined antiplatelet therapy
Autore:
Atalar, E; Aytemir, K; Haznedaroglu, I; Aksoyek, S; Ovunc, K; Kirazli, S; Ozmen, F;
Indirizzi:
Univ Hacettepe, Fac Med, Dept Cardiol, TR-06100 Ankara, Turkey Univ Hacettepe Ankara Turkey TR-06100 t Cardiol, TR-06100 Ankara, Turkey Univ Hacettepe, Fac Med, Dept Hematol, TR-06100 Ankara, Turkey Univ Hacettepe Ankara Turkey TR-06100 t Hematol, TR-06100 Ankara, Turkey
Titolo Testata:
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
fascicolo: 2, volume: 7, anno: 2001,
pagine: 116 - 121
SICI:
1076-0296(200104)7:2<116:PALDAI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULES ICAM-1; GRANULE MEMBRANE-PROTEIN; CORONARY ANGIOPLASTY; E-SELECTIN; ENDOTHELIAL-CELLS; P-SELECTIN; ACTIVATION; THROMBOSIS; MONOCYTES; NEUTROPHIL;
Keywords:
adhesion molecules; intracoronary stents; leukocytes; platelets; ticlopidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Atalar, E Koymenevler Koop,2 Blok,4 Cayyolu, TR-06530 Ankara, Turkey Koymenevler Koop,2 Blok,4 Cayyolu Ankara Turkey TR-06530 urkey
Citazione:
E. Atalar et al., "Platelet and leukocyte deactivation after intracoronary stent placement inpatients receiving combined antiplatelet therapy", CL APPL T-H, 7(2), 2001, pp. 116-121

Abstract

Activated platelets and leukocytes have been demonstrated to play a role in the development of stent thrombosis, and coronary angioplasty has been shown to result in activation of platelets, leukocytes, and endothelial cells. We aimed to evaluate the effects of intracoronary stent placement and aspirin plus ticlopidine treatment on platelets, leukocytes, and endothelial cells via observing the serial changes in the circulating soluble forms of adhesion molecules in 54 patients with coronary artery disease, who had elective coronary angioplasty and stent implantation for a single lesion of theleft anterior descending artery. After stent placement, intravenous heparin infusion was administered only for 24 hours, and aspirin plus ticlopidinetreatment was applied for 1 month. Venous blood samples were drawn before stent placement, and repeated 24 and 48 hours after the procedure. Patientswere excluded if they had had recent cardiovascular events or any illness that might influence platelet, leukocyte, and endothelial cell function. The plasma level of sL-selectin was significantly decreased 48 hours after coronary stenting (636 +/- 110 ng/mL vs 567 +/- 93 ng/mL; P = 0.001, respectively). Likewise, the plasma level of sP-selectin was also decreased significantly 48 hours after the procedure (260 +/- 61 ng/mL vs 233 +/- 83 ng/mL, P = 0.01). The sE-selectin level was found to be significantly increased 24hours (31 +/- 9 ng/mL vs 39 +/- 12 ng/mL, P = 0.0001) and 48 hours(31 +/- 9 ng/mL vs 42 +/- 15 ng/mL, P = 0.001) after coronary stenting. The resultsof our study suggest that significant platelet and leukocyte deactivation take place in patients treated with combined antiplatelet therapy after stenting; endothelial cell activation also occurs during this treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:55:14