Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Carboxypeptidase U at the interface between coagulation and fibrinolysis
Autore:
Schatteman, K; Goossens, F; Leurs, J; Verkerk, R; Scharpe, S; Michiels, JJ; Hendriks, D;
Indirizzi:
Univ Antwerp, Dept Pharmaceut Sci, Med Biochem Lab, B-2610 Wilrijk, Belgium Univ Antwerp Wilrijk Belgium B-2610 Biochem Lab, B-2610 Wilrijk, Belgium
Titolo Testata:
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
fascicolo: 2, volume: 7, anno: 2001,
pagine: 93 - 101
SICI:
1076-0296(200104)7:2<93:CUATIB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-C; THROMBIN-THROMBOMODULIN COMPLEX; PLASMA PROCARBOXYPEPTIDASE-B; TISSUE PLASMINOGEN-ACTIVATOR; FACTOR-V-LEIDEN; BLOOD-COAGULATION; CLOT LYSIS; BINDING-SITES; EXTRINSIC PATHWAY; FACTOR-VIIA;
Keywords:
carboxypeptidase U; coagulation; fibrinolysis; thrombin-activable fibrinolysis inhibitor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
113
Recensione:
Indirizzi per estratti:
Indirizzo: Hendriks, D Univ Antwerp, Dept Pharmaceut Sci, Med Biochem Lab, Univ Pl 1,B-2610 Wilrijk, Belgium Univ Antwerp Univ Pl 1 Wilrijk Belgium B-2610 ilrijk, Belgium
Citazione:
K. Schatteman et al., "Carboxypeptidase U at the interface between coagulation and fibrinolysis", CL APPL T-H, 7(2), 2001, pp. 93-101

Abstract

In 1988, Hendricks et al. first reported on the presence of carboxypeptidase U (U refers to the unstable nature of the enzyme) in human serum. One decade later, the importance of carboxypeptidase U (CPU) in the regulation offibrin clot dissolution is well documented. CPU circulates in plasma as aninactive zymogen, proCPU, that is converted to its active form during coagulation and fibrinolysis. CPU cleaves off C-terminal lysine residues exposed on fibrin partially degraded by the action of plasmin. Because these C-terminal lysine residues are important for upregulating the fibrinolytic rate, CPU thus slows down fibrinolysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:37:50