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Titolo:
Fast high-resolution magnetic resonance imaging demonstrates fractality ofmyocardial perfusion in microscopic dimensions
Autore:
Bauer, WR; Hiller, KH; Galuppo, P; Neubauer, S; Kopke, J; Haase, A; Waller, C; Ertl, G;
Indirizzi:
Univ Wurzburg, Med Klin, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 d Klin, D-97080 Wurzburg, Germany Univ Oxford, John Redcliffe Hosp, Dept Cardiovasc Med, Oxford OX1 2JD, England Univ Oxford Oxford England OX1 2JD rdiovasc Med, Oxford OX1 2JD, England Univ Heidelberg, Klinikum Mannheim, Inst Rontgendiagnost, D-6900 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-6900 st, D-6900 Heidelberg, Germany Univ Wurzburg, Inst Phys, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 t Phys, D-97070 Wurzburg, Germany
Titolo Testata:
CIRCULATION RESEARCH
fascicolo: 3, volume: 88, anno: 2001,
pagine: 340 - 346
SICI:
0009-7330(20010216)88:3<340:FHMRID>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED RAT-HEART; ARTERIAL WATER; BLOOD-FLOW; COLORED MICROSPHERES; CORONARY VESSELS; BRAIN PERFUSION; SPIN INVERSION; IN-VIVO; NMR; HETEROGENEITY;
Keywords:
magnetic resonance imaging; perfusion; microcirculation; fractality;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Bauer, WR Univ Wurzburg, Med Klin, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080 ny
Citazione:
W.R. Bauer et al., "Fast high-resolution magnetic resonance imaging demonstrates fractality ofmyocardial perfusion in microscopic dimensions", CIRCUL RES, 88(3), 2001, pp. 340-346

Abstract

The fractal nature of heterogeneity of myocardial blood flow and its implications for the healthy and diseased heart is not yet understood. The main hindrance for investigation of blood flow heterogeneity and its role in physiology and pathophysiology is that conventional methods for determination of myocardial perfusion have severe limitations concerning temporal and spatial resolution and invasiveness. In isolated rat hearts, we developed a nuclear magnetic resonance technique that does not depend on contrast agents and in which the apparent longitudinal relaxation time is made perfusion sensitive by selective preparation of the imaging slice. This perfusion-sensitive relaxation time is determined within 40 seconds as a map with a high spatial in-plane resolution of 140x140 mum(2) and a thickness of 1.5 mm. Perfusion imaging was validated with the established microsphere technique. Additionally, the congruence between perfusion-sensitive T-1 maps and first-pass perfusion imaging was demonstrated. As an application of high-resolution perfusion imaging, fractal analysis of the spatial distribution of perfusion was performed. We were able to demonstrate that the fractality of this distribution exists even in microscopic dimensions. Vasodilation by nitroglycerin modulated the fractal pattern of perfusion, and the decrease of the fractal dimension indicated a shift toward homogeneity. This implies that parameters of the fractal distribution depend on the microvascular tone rather than on anatomic preformations; ie, fractality is a functional characteristic of perfusion.

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Documento generato il 08/07/20 alle ore 00:07:53