Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Reverse mode of the Na+-Ca2+ exchange after myocardial stretch - Underlying mechanism of the slow force response
Autore:
Perez, NG; de Hurtado, MCC; Cingolani, HE;
Indirizzi:
Natl Univ La Plata, Fac Ciencias Med, Ctr Invest Cardiovasc, RA-1900 La Plata, Argentina Natl Univ La Plata La Plata Argentina RA-1900 A-1900 La Plata, Argentina
Titolo Testata:
CIRCULATION RESEARCH
fascicolo: 4, volume: 88, anno: 2001,
pagine: 376 - 382
SICI:
0009-7330(20010302)88:4<376:RMOTNE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT VENTRICULAR MYOCYTES; ENDOTHELIN-CONVERTING ENZYME-2; ANGIOTENSIN-II RECEPTORS; NA+/CA2+ EXCHANGE; CARDIAC FIBROBLASTS; INDUCED HYPERTROPHY; INTRACELLULAR PH; PAPILLARY-MUSCLE; CA2+ TRANSIENT; CELLS;
Keywords:
myocardial stretch; Na+-Ca2+ exchange; Na+-H+ exchange; angiotensin II; endothelin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Cingolani, HE Natl Univ La Plata, Fac Ciencias Med, Ctr Invest Cardiovasc,60 & 120, RA-1900 La Plata, Argentina Natl Univ La Plata 60 & 120 La Plata Argentina RA-1900 tina
Citazione:
N.G. Perez et al., "Reverse mode of the Na+-Ca2+ exchange after myocardial stretch - Underlying mechanism of the slow force response", CIRCUL RES, 88(4), 2001, pp. 376-382

Abstract

This study was designed to gain additional insight into the mechanism of the slow force response (SFR) to stretch of cardiac muscle. SFR and changes in intracellular Na+ concentration ([Na+](i)) were assessed in cat papillary muscles stretched from 92% to approximate to 98% of L-max. The SFR was 120+/-0.6% (n=5) of the rapid initial phase and coincided with an increase in[Na+](i). The SFR was markedly depressed by Na+-H+ exchanger inhibition, AT(1) receptor blockade, nonselective endothelin-receptor blockade and selective ETA-receptor blockade, extracellular Na+ removal, and inhibition of the reverse mode of the Na+-Ca2+ exchange by KB-R7943. KB-R7943 prevented theSFR but not the increase in [Na+](i). Inhibition of endothelin-converting enzyme activity by phosphoramidon suppressed both the SFR and the increase in [Na+](i). The SFR and the increase in [Na+](i) after stretch were both present in muscles with their endothelium (vascular and endocardial) made functionally inactive by Triton X-100. In these muscles, phosphoramidon also suppressed the SFR and the increase in [Na+](i). The data provide evidence that the last step of the autocrine-paracrine mechanism leading to the SFR to stretch is Ca2+ entry through the reverse mode of Na+-Ca2+ exchange.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:14:17