Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease
Autore:
Wu, KK; Aleksic, N; Ahn, C; Boerwinkle, E; Folsom, AR; Juneja, H;
Indirizzi:
Univ Texas, Houston Med Sch, Div Hematol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 d Sch, Div Hematol, Houston, TX 77030 USA Univ Texas, Houston Med Sch, Vasc Biol Res Ctr, Houston, TX 77030 USA UnivTexas Houston TX USA 77030 Vasc Biol Res Ctr, Houston, TX 77030 USA Univ Texas, Houston Hlth Sci Ctr, Vasc Biol Res Ctr, Houston, TX USA Univ Texas Houston TX USA th Sci Ctr, Vasc Biol Res Ctr, Houston, TX USA Univ Texas, Houston Hlth Sci Ctr, Div Hematol, Dept Internal Med, Houston,TX USA Univ Texas Houston TX USA Div Hematol, Dept Internal Med, Houston,TX USA Univ Texas, Houston Hlth Sci Ctr, Dept Internal Med, Div Gen Med, Houston,TX USA Univ Texas Houston TX USA Dept Internal Med, Div Gen Med, Houston,TX USA Univ Texas, Houston Hlth Sci Ctr, Dept Human Genet, Houston, TX USA Univ Texas Houston TX USA lth Sci Ctr, Dept Human Genet, Houston, TX USA Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 demiol, Minneapolis, MN 55455 USA
Titolo Testata:
CIRCULATION
fascicolo: 10, volume: 103, anno: 2001,
pagine: 1386 - 1389
SICI:
0009-7322(20010313)103:10<1386:TAPARO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID DIMORPHISM; MYOCARDIAL-INFARCTION; ATHEROSCLEROSIS RISK; TISSUE-FACTOR; CASE-COHORT; GENE; CHOLESTEROL; MUTATION; SURFACE;
Keywords:
thrombomodulin; genetics; coronary disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, KK Univ Texas, Houston Med Sch, Div Hematol, 6431 Fannin,MSB 5-016, Houston, TX 77030 USA Univ Texas 6431 Fannin,MSB 5-016 Houston TX USA 77030 TX 77030 USA
Citazione:
K.K. Wu et al., "Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease", CIRCULATION, 103(10), 2001, pp. 1386-1389

Abstract

Background-Thrombomodulin (TM) is expressed on the endothelial surface andplays an important role in vasoprotection. A common polymorphism of TM at amino acid position 455 with an alanine (A) to valine (V) transition was previously reported to be associated cross-sectionally with acute myocardial infarction. Whether this single nucleotide polymorphism predicts risk of developing coronary heart disease (CHD) is unclear. Methods and Results-Within a large cohort study, we identified 467 incident CHD cases during an average of 5 years of follow-up. We determined TM-455genotypes on 376 CHD cases (23% black, 77% white) and a reference sample of 461. The AA genotype was significantly more prevalent in noncases than incases (P=0.016), The prevalences of the AA genotype in noncase blacks and whites were 93% and 67%, respectively. The AA genotype frequency was significantly reduced in black cases versus noncases (P=0.018). It was also lowerin white cases than in noncases, but the difference was not statistically significant (P=0.066), Weighted proportional hazards regression analysis after adjustment for age, sex, and other CHD risk factors showed that having the V allele increased risk of CHD by 6.1-fold (risk ratio 6.1, 95% CI 1.7 to 22.9) in blacks but did not significantly increase the risk in whites. Conclusions-The TM A455V polymorphism predicts risk of developing CHD in blacks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:57:12