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Titolo:
Right bundle branch block, right precordial ST-segment elevation, and sudden death in young people
Autore:
Corrado, D; Basso, C; Buja, G; Nava, A; Rossi, L; Thiene, G;
Indirizzi:
Univ Padua, Sch Med, Dept Cardiol, I-35121 Padua, Italy Univ Padua PaduaItaly I-35121 h Med, Dept Cardiol, I-35121 Padua, Italy Univ Padua, Sch Med, Dept Pathol, I-35121 Padua, Italy Univ Padua Padua Italy I-35121 ch Med, Dept Pathol, I-35121 Padua, Italy
Titolo Testata:
CIRCULATION
fascicolo: 5, volume: 103, anno: 2001,
pagine: 710 - 717
SICI:
0009-7322(20010206)103:5<710:RBBBRP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RIGHT-VENTRICULAR CARDIOMYOPATHY; BRUGADA-SYNDROME; HEART-DISEASE; CARDIAC DEATH; ELECTROPHYSIOLOGICAL RESPONSE; UNDERLIES SYNDROME; CELLULAR BASIS; FIBRILLATION; EPICARDIUM; DYSPLASIA;
Keywords:
arrhythmogenic right ventricular dysplasia fibrillation; death, sudden;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Thiene, G Univ Padua, Ist Anat Patol, Via A Gabelli 61, I-35121 Padua, Italy Univ Padua Via A Gabelli 61 Padua Italy I-35121 21 Padua, Italy
Citazione:
D. Corrado et al., "Right bundle branch block, right precordial ST-segment elevation, and sudden death in young people", CIRCULATION, 103(5), 2001, pp. 710-717

Abstract

Background-Patients with the ECG pattern of right bundle branch block and right precordial ST-segment elevation may experience sudden death in the setting of either arrhythmogenic right ventricular cardiomyopathy (ARVC) or afunctional electrical disorder such as Brugada syndrome. Methods and Results-Among a series of 273 young (less than or equal to 35 years) victims of cardiovascular sudden death who were prospectively studied from 1979 to 1998 in the Veneto Region of Italy, 12-lead ECG was available in 96 cases, Thirteen (14%; 12 males and 1 female aged 24+/-8 years) had right precordial ST-segment elevation, either isolated (9 cases) or associated with right bundle branch block (4 cases). At autopsy, all patients had ARVC (92%) except one, who had no evidence of structural heart disease. Compared with the 19 young sudden death victims with ARVC and no ST-segment abnormalities from the same series, those with AVRC and right precordial ST-segment elevation included fewer competitive athletes (17% versus 58%, P=0.03), more often died suddenly at rest or during sleep (83% versus 26%; P=0.003), and showed serial ECG changes over time (83% versus 0; P=0.015), polymorphic ventricular tachycardia (33% versus 0; P=0.016), and predominant fatty replacement of the right ventricular anterior wall (58% versus 21%; P=0.05). Conclusions-Right precordial ST-segment elevation was found in 14% of young sudden death victims with available EGG. It mostly reflected underlying ARVC with predominant right ventricular anterior wall involvement and characterized a subgroup of patients who share with Brugada patients the propensity to die from non-exercise-related cardiac arrest and to exhibit dynamic ECG changes and polymorphic ventricular tachycardia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:52:25