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Titolo:
Inducible nitric oxide synthase deficiency does not affect the susceptibility of mice to atherosclerosis but increases collagen content in lesions
Autore:
Niu, XL; Yang, X; Hoshiai, K; Tanaka, K; Sawamura, S; Koga, Y; Nakazawa, H;
Indirizzi:
Tokai Univ, Sch Med, Dept Physiol, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 Dept Physiol, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Microbiol, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 ept Microbiol, Kanagawa 2591193, Japan
Titolo Testata:
CIRCULATION
fascicolo: 8, volume: 103, anno: 2001,
pagine: 1115 - 1120
SICI:
0009-7322(20010227)103:8<1115:INOSDD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN OXIDATION; SMOOTH-MUSCLE CELLS; IN-VIVO; PEROXYNITRITE; GENE; EXPRESSION; INHIBITION; ARTERIOSCLEROSIS; INFECTION; PROMOTES;
Keywords:
mice, inbred; atherosclerosis; nitric oxide synthase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Nakazawa, H Tokai Univ, Sch Med, Dept Physiol, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 l, Kanagawa 2591193, Japan
Citazione:
X.L. Niu et al., "Inducible nitric oxide synthase deficiency does not affect the susceptibility of mice to atherosclerosis but increases collagen content in lesions", CIRCULATION, 103(8), 2001, pp. 1115-1120

Abstract

Background-Although endothelial nitric oxide synthase (NOS) is antiatherogenic, the role of inducible NOS (iNOS) in the development: of atherosclerosis is not established. Methods and Results-We compared the susceptibility of iNOS knockout (iNOS(-/-)) and wild-type (iNOS(+/+)) mice to the development of atherosclerosis induced by feeding an atherogenic diet for 15 weeks. Plasma lipid level, atherosclerotic lesion size, and cellular density in the lesions were all similar in the 2 strains (lesion size: iNOS(+/+) 285+/-73x10(3) mum(2), iNOS(-/-) 293+/-82x10(3) mum(2), n=10). iNOS mRNA was detected in the lesions of iNOS(+/+) but not iNOS(-/-) mice through RT-PCR. Immunohistochemically, iNOS(+/+) mice showed iNOS staining in macrophages and medial smooth muscle cells in the lesions. Nitrotyrosine staining showed a similar distribution, whereas it was absent in iNOS(-/-) mice. There was no apparent difference inthe intensity or distribution of vascular eel adhesion molecule-1 stainingin the lesions of the 2 strains. However, the lesions of iNOS(+/+) mice showed a markedly decreased extracellular collagen content compared with those of iNOS(-/-) mice. Conclusions-iNOS induction does not affect the development of atherosclerosis in mice fed an atherogenic diet, but the resulting lesions show decreased levels of extracellular collagen and may be more fragile.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:35:16