Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Modulation of BmKAS-1 and BmK1-3-2 to sodium channel in rat dorsal root ganglion neurons
Autore:
Xiao, H; Mao, X; Tan, ZY; Shi, Y; Zhao, ZQ; Ji, YH;
Indirizzi:
Nanjing Med Univ, Appl Inst Toxicol, Dept Neurotoxicol, Nanjing 210029, Peoples R China Nanjing Med Univ Nanjing Peoples R China 210029 210029, Peoples R China Chinese Acad Sci, Shanghai Inst Physiol, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China
Titolo Testata:
CHINESE MEDICAL JOURNAL
fascicolo: 3, volume: 114, anno: 2001,
pagine: 253 - 256
SICI:
0366-6999(200103)114:3<253:MOBABT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BUTHUS-MARTENSI KARSCH; BMK; PAIN;
Keywords:
patch-clamp; BmKAS-1; BmK1-3-2; dorsal root ganglion; sodium channel;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Xiao, H Nanjing Med Univ, Appl Inst Toxicol, Dept Neurotoxicol, 140 Hanzhong Rd, Nanjing 210029, Peoples R China Nanjing Med Univ 140 Hanzhong Rd Nanjing Peoples R China 210029 a
Citazione:
H. Xiao et al., "Modulation of BmKAS-1 and BmK1-3-2 to sodium channel in rat dorsal root ganglion neurons", CHIN MED J, 114(3), 2001, pp. 253-256

Abstract

Objective To investigate what effects BmKAS-1 (a polypeptide purified fromthe Chinese scorpion Buthus martensi Karsch [BmK] and named as BmK activator of skeletal-muscle ryanodine receptor) and its upstream mixture BmK1-3-2have on Na+ channels in dorsal root ganglion (DRG) small diameter neurons. Methods The whole-cell patch-clamp technique was used to investigate the effects of BmKAS-1 and BmK1-3-2 on Na+ current in rat small diameter DRG neurons. Results About 50% peak Na+ current was suppressed by 10 mug/ml of BmK1-3-2. 1.62 mug/ml of BmKAS-1 also blocked 50% peak Na+ current, and there was an obvious dose-dependent relationship. Conclusion Both BmK1-3-2 and BmKAS-1 have a blocking effect on Na+ channels, and this may one of the mechanisms for the analgetic effect of BmK1-3-2 and BmKAS-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 22:18:47