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Titolo:
Pulmonary cytomegalovirus infection in immunocompromised patients
Autore:
Tamm, M; Traenkle, P; Grilli, B; Soler, M; Bolliger, CT; Dalquen, P; Cathomas, G;
Indirizzi:
Univ Basel Hosp, Div Pneumol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ol, CH-4031 Basel, Switzerland Univ Basel Hosp, Dept Internal Med, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ed, CH-4031 Basel, Switzerland Univ Basel Hosp, Inst Pathol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ol, CH-4031 Basel, Switzerland
Titolo Testata:
CHEST
fascicolo: 3, volume: 119, anno: 2001,
pagine: 838 - 843
SICI:
0012-3692(200103)119:3<838:PCIIIP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MARROW TRANSPLANT RECIPIENTS; BRONCHOALVEOLAR LAVAGE; VIRUS PNEUMONIA; RAPID DETECTION; CULTURE; FLUID; AIDS; HIV; DIAGNOSIS; CELLS;
Keywords:
BAL; cytomegalovirus infection; cytomegalovirus immunostaining;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Tamm, M Univ Basel Hosp, Div Pneumol, Petersgraben 4, CH-4031 Basel, Switzerland Univ Basel Hosp Petersgraben 4 Basel Switzerland CH-4031 tzerland
Citazione:
M. Tamm et al., "Pulmonary cytomegalovirus infection in immunocompromised patients", CHEST, 119(3), 2001, pp. 838-843

Abstract

Background: Cytomegalovirus (CMV) infection and CMV disease are frequent complications in immunocompromised patients. In this study the incidence of pulmonary CMV infection was analyzed in different groups of immunocompromised patients and the diagnostic value of immunostaining with anti-CMV antibodies in BAL cells was evaluated in regard to the diagnosis of CMV pneumonitis. Methods: Five hundred eighty consecutive BAL procedures were analyzed prospectively in 442 immunocompromised and 126 nonimmunocompromised control subjects. Ch IV culture in BAL fluid was performed by shell vial assay and immunostaining using three monoclonal anti-CMV antibodies. Results: The incidence of culture results positive for CMV in the BAL fluid varied from 20 to 30% in HIV-positive patients, in patients following stem cell or renal transplantation, and in patients with autoimmune disease orlung fibrosis treated with immunosuppressive agents. CMV was cultured from4.4% of BALs in patients treated with high-dose chemotherapy and from 2.4%of control subjects. CMV disease developed in 37 patients; in 18 of these patients, CMV pneumonitis was present. The results of CMV immunostaining were positive in a total of 22 BALs, ail in patients with CMV disease. The sensitivity specificity, and positive and negative predictive values of positive CMV immunostaining results for the diagnosis of CMV pneumonitis were 88.90%, 98.6%, 72.7%, and 99.5%, respectively. Conclusion: The incidence of pulmonary CMV infection is similar in different groups of immunocompromised patients except for patients following high-dose chemotherapy. CMV immunostaining in the BAL fluid is a very helpful method to diagnose CMV pneumonitis in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:23:15