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Titolo:
Association of airway responsiveness with asthma and persistent wheeze in a Chinese population
Autore:
Xu, XP; Niu, TH; Chen, CZ; Wang, BY; Jin, YT; Yang, JH; Weiss, ST;
Indirizzi:
Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 gram Populat Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Channing Lab, Boston, MA USA Harvard Univ Boston MA USA s Hosp, Dept Med,Channing Lab, Boston, MA USA Anhui Meizhong Inst Biomed Sci & Environm Hlth, Anhua, Peoples R China Anhui Meizhong Inst Biomed Sci & Environm Hlth Anhua Peoples R China na Anhui Med Univ, Ctr Ecogenet & Dis Control, Hefei, Anhui, Peoples R China Anhui Med Univ Hefei Anhui Peoples R China Hefei, Anhui, Peoples R China
Titolo Testata:
CHEST
fascicolo: 3, volume: 119, anno: 2001,
pagine: 691 - 700
SICI:
0012-3692(200103)119:3<691:AOARWA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSPECIFIC BRONCHIAL RESPONSIVENESS; RESPIRATORY SYMPTOMS; PULMONARY-FUNCTION; PREVALENCE; HYPERRESPONSIVENESS; CHILDREN; REACTIVITY; SCHOOLCHILDREN; QUESTIONNAIRE; METHACHOLINE;
Keywords:
airway responsiveness; asthma; wheeze;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, XP Harvard Univ, Sch Publ Hlth, Program Populat Genet, FXB-101,665 HuntingtonAve, Boston, MA 02115 USA Harvard Univ FXB-101,665 Huntington Ave Boston MA USA 02115 115 USA
Citazione:
X.P. Xu et al., "Association of airway responsiveness with asthma and persistent wheeze in a Chinese population", CHEST, 119(3), 2001, pp. 691-700

Abstract

Study objectives: Data from a cross-sectional study were analyzed to examine the association of increased airway responsiveness with physician-diagnosed asthma and persistent wheeze. Design: Two methods for calculating the provocative dose that decreases the airflow rate by 20% (PD50) were used as indexes for increased airway responsiveness: (1) a 20% drop in FEV1 calculated from baseline FEV1 (PD(20)b),and (2) a 20% drop in FEV, from FEV, measurements after inhalation of saline solution (PD(20)s), Both PD(20)b and PD(20)s were measured through induction bq varying doses of methacholine. Setting: Anqing, Anhui Province, China. Participants: Study subjects were 8 to 74 years of age and were classifiedinto four groups: children (< 15 years old), young adults (15 to 29 years old), adults (30 to 44 years old), and older adults (<greater than or equalto> 45 years old). Interventions: The differences in estimated odds ratios of airway hyperresponsiveness with asthma and wheeze, sensitivity and specificity and coefficients of variation were compared between PD(20)b and PD(20)s, The sample For analysis consisted of 10,284 subjects from 2,663 nuclear families with complete data on wheeze, asthma, and major potential confounding factors. Measurements and results: The prevalence of asthma in this sample was lowest in subjects with no demonstrable PD20 and had a reverse dose-response relationship with PD20 across all age groups. Using the receiver operating characteristic, the sensitivity and specificity of the PD(20)s or PD(20)b were found to be almost identical. A similar trend was found for persistent wheeze, although the estimated odds ratios for persistent wheeze appeared slightly smaller than those for physician-diagnosed asthma,Conclusions: This study demonstrates a dose-response relationship between increased airway responsiveness and asthma and wheeze in this Chinese population. PD(20)s or PD(20)b yielded virtually indistinguishable results, which indicated that either of the two tests: could serve as an index of airwayhyperresponsiveness.

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Documento generato il 16/02/20 alle ore 23:50:13