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Titolo:
Prediction of the final infarct volume within 6 h of stroke using single photon emission computed tomography with technetium-99m hexamethylpropylene amine oxime
Autore:
Hirano, T; Read, SJ; Abbott, DF; Baird, AE; Yasaka, M; Infeld, B; Barber, PA; Davis, SM; McKay, WJ; Donnan, GA;
Indirizzi:
Austin & Repatriat Med Ctr, Boronia Ctr, Natl Stroke Res Inst, Dept Neurol, W Heidelberg, Vic 3081, Australia Austin & Repatriat Med Ctr W Heidelberg Vic Australia 3081 081, Australia Austin & Repatriat Med Ctr, Dept Nucl Med, W Heidelberg, Vic 3081, Australia Austin & Repatriat Med Ctr W Heidelberg Vic Australia 3081 081, Australia Royal Melbourne Hosp, Dept Neurol, Melbourne, Vic, Australia Royal Melbourne Hosp Melbourne Vic Australia , Melbourne, Vic, Australia
Titolo Testata:
CEREBROVASCULAR DISEASES
fascicolo: 2, volume: 11, anno: 2001,
pagine: 119 - 127
SICI:
1015-9770(2001)11:2<119:POTFIV>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE ISCHEMIC STROKE; TC-99M HMPAO SPECT; THROMBOLYTIC THERAPY; CEREBRAL INFARCTION; FLOW THRESHOLDS; BRAIN-TISSUE; BLOOD-FLOW; PERFUSION; REPERFUSION; STREPTOKINASE;
Keywords:
stroke; cerebral infarction; cerebral ischemia; single photon emission tomograpy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Donnan, GA Austin & Repatriat Med Ctr, Boronia Ctr, Natl Stroke Res Inst, Dept Neurol, Level 1,Repat Campus,Bell St, W Heidelberg, Vic 3081, Australia Austin & Repatriat Med Ctr Level 1,Repat Campus,Bell St W Heidelberg Vic Australia 3081
Citazione:
T. Hirano et al., "Prediction of the final infarct volume within 6 h of stroke using single photon emission computed tomography with technetium-99m hexamethylpropylene amine oxime", CEREB DIS, 11(2), 2001, pp. 119-127

Abstract

Background: A simple method to predict the final infarct volume within 6 hof onset of hemispheric ischemic stroke based on the measurement of cerebral blood flow (CBF) using single photon emission computed tomography (SPECT) with techneticum-99m hexamethylpropylene amine oxime (Tc-99m-HMPAO) was investigated in a clinical model involving patients without definite early reperfusion or clinical recovery. Methods: A group of 16 patients (group 1) was used to establish the methodology, which was then validated in a secondgroup of 14 patients (group 2). The final infarct volume was defined usingcomputed tomography (CT) performed at least 7 days after stroke. The relative CBF threshold value, expressed as a percentage of the mean contralateral hemispheric value, which most closely estimated the final infarct size oncoregistered CT was established for each patient. Results: The mean threshold CBF value for group 1 was 63.7%. When this value was used to predict infarct size in group 2, a close correlation was observed between the actual and the estimated sizes (r = 0.973, p < 0.0001). This value was not time dependent. Conclusions: If no significant early reperfusion or clinical recovery occurs, a CBF threshold value of 63.7% on Tc-99m-HMPAO SPECT performed within 6 h of stroke onset will reliably predict the final infarct size. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:11:10