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Titolo:
Twenty-four-hour blood pressure changes in the course of lacunar disease
Autore:
Yamamoto, Y; Akiguchi, I; Oiwa, K; Hayashi, M; Imai, K;
Indirizzi:
Kyoto Second Red Cross Hosp, Dept Neurol, Kamigyo Ku, Kyoto 602, Japan Kyoto Second Red Cross Hosp Kyoto Japan 602 Kamigyo Ku, Kyoto 602, Japan Kyoto Univ Hosp, Kyoto 606, Japan Kyoto Univ Hosp Kyoto Japan 606Kyoto Univ Hosp, Kyoto 606, Japan
Titolo Testata:
CEREBROVASCULAR DISEASES
fascicolo: 2, volume: 11, anno: 2001,
pagine: 100 - 106
SICI:
1015-9770(2001)11:2<100:TBPCIT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGE-RELATED-CHANGES; CEREBROVASCULAR-DISEASE; HYPERTENSIVE PATIENTS; COGNITIVE IMPAIRMENT; ELDERLY PEOPLE; STROKE; FRAMINGHAM; PATTERNS; DEMENTIA; INFARCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamoto, Y Kyoto Second Red Cross Hosp, Dept Neurol, Kamigyo Ku, 355-5 Haruobicho, Kyoto 602, Japan Kyoto Second Red Cross Hosp 355-5 Haruobicho Kyoto Japan 602
Citazione:
Y. Yamamoto et al., "Twenty-four-hour blood pressure changes in the course of lacunar disease", CEREB DIS, 11(2), 2001, pp. 100-106

Abstract

Background: Changes in blood pressure (BP) over time have not been considered in investigations on the relationship between BP and cerebrovascular disease (CVD). Objective: To investigate BP changes throughout a 24-hour period in lacunar infarct patients with different outcomes. Methods: Twelve control subjects (group 1) and 56 patients with symptomatic lacunar infarcts were studied. The infarct patients were divided into three groups: group 2, 25 patients with a fair outcome without any cerebrovascular attack or progressive dementia (mean follow-up period: 4.4 years); group 3, 14 patients with worsening of clinical dementia rating and silent lesions, which includedlacunae and diffuse white matter lesions (4.5 years), and group 4, 17 patients who developed symptomatic infarcts (1.7 years). MRIs and ambulatory BPmonitoring were performed for each patient on two separate occasions. No patient was treated with antihypertensive agents during the course of the study. Results: In group 2, the second measurements were significantly higherthan the first for 24-hour systolic BP (SBP), daytime SEP, 24-hour diastolic BP (DBP), daytime DBP (p < 0.01, for all) and nighttime DBP (p < 0.05). In group 3, the second measurements were significantly lower than the firstfor 24-hour SBP, daytime SBP, 24-hour DBP, and daytime DBP (p < 0.01, for all). In group 4, the second measurements were significantly lower than thefirst for 24-hour SEP and daytime SEP (p < 0.01). The correlation between BP and pulse rate became positive for group 2 in second measurements, but was not positive for groups 3 and 4. Conclusions: BP tended to elevate over time in patients with a fair outcome. In contrast, BP tended to decrease inthose who developed dementia and symptomatic infarct. Autonomic functions including sympathetic activity might play a role in changes in BP in lacunar infarct patients during the course of disease. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:09:22