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Titolo:
Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBF beta
Autore:
Tahirov, TH; Inoue-Bungo, T; Morii, H; Fujikawa, A; Sasaki, M; Kimura, K; Shiina, M; Sato, K; Kumasaka, T; Yamamoto, M; Ishii, S; Ogata, K;
Indirizzi:
Yokohama City Univ, Sch Med, Kanagawa Acad Sci & Technol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Yokohama City Univ, Sch Med, Dept Biol Struct, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Yokohama City Univ, Sch Med, Dept Urol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Yokohama City Univ, Sch Med, Dept Pathol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Yokohama City Univ, Sch Med, Dept Biochem, Kanazawa Ku, Yokohama, Kanagawa2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 Kanagawa2360004, Japan Natl Inst Biosci & Human Technol, Prot Folding Grp, Tsukuba, Ibaraki 3058566, Japan Natl Inst Biosci & Human Technol Tsukuba Ibaraki Japan 3058566 566, Japan RIKEN, Harima Inst SPring 8, Biocrystallog Technol Div, Sayo, Hyogo 6795148, Japan RIKEN Sayo Hyogo Japan 6795148 og Technol Div, Sayo, Hyogo 6795148, Japan RIKEN, Harima Inst SPring 8, Struct Biophys Lab, Sayo, Hyogo 6795148, Japan RIKEN Sayo Hyogo Japan 6795148 ct Biophys Lab, Sayo, Hyogo 6795148, Japan JST, Res Project, CREST, Tsukuba, Ibaraki 3050074, Japan JST Tsukuba Ibaraki Japan 3050074 CREST, Tsukuba, Ibaraki 3050074, Japan RIKEN, Tsukuba Inst, Genet Mol Lab, Tsukuba, Ibaraki 3050074, Japan RIKENTsukuba Ibaraki Japan 3050074 Lab, Tsukuba, Ibaraki 3050074, Japan
Titolo Testata:
CELL
fascicolo: 5, volume: 104, anno: 2001,
pagine: 755 - 767
SICI:
0092-8674(20010309)104:5<755:SAODRB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORE-BINDING-FACTOR; TRANSCRIPTION FACTOR PEBP2; ACUTE MYELOID-LEUKEMIA; CLEIDOCRANIAL DYSPLASIA; CRYSTAL-STRUCTURE; POINT MUTATIONS; AML1/PEBP2-ALPHA-B GENE; FUNCTIONAL DOMAINS; CYSTEINE RESIDUES; ALPHA-SUBUNIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Ogata, K Yokohama City Univ, Sch Med, Kanagawa Acad Sci & Technol, Kanazawa Ku, 3-9Fukuura, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ 3-9 Fukuura Yokohama Kanagawa Japan 2360004 an
Citazione:
T.H. Tahirov et al., "Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBF beta", CELL, 104(5), 2001, pp. 755-767

Abstract

The core binding factor (CBF) heterodimeric transcription factors comprised of AML/CBFA/PEBPSalpha/Runx and CBF beta /PEBP2 beta subunits are essential for differentiation of hematopoietic and bone cells, and their mutation is intimately related to the development of acute leukemias and cleidocranial dysplasia. Here, we present the crystal structures of the AML1/Runx-1/CBF alpha (Runt domain)-CBF beta (core domain)-C/EBP beta (b-Zip)-DNA, AML1/Runx-1/CBF alpha (Runt domain)-C/EBP beta (bZip)-DNA, and AML1/Runx-1/CBF alpha (Runt domain)DNA complexes. The hydrogen bonding network formed among CBF alpha (Runt domain) and CBF beta, and CBF alpha (Runt domain) and DNA revealed the allosteric regulation mechanism of CBF alpha (Runt domain)-DNA binding by CBF beta. The point mutations of CBF alpha related to the aforementioned diseases were also mapped and their effect on DNA binding is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:35:55