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Titolo:
Treatment of kidney cancer with autologous tumor cell vaccines of short-term cell lines derived from renal cell carcinoma
Autore:
Dillman, RO; Barth, NM; VanderMolen, LA; Garfield, DH; De Leon, C; OConnor, AA; Mahdavi, K; Nayak, SK;
Indirizzi:
Hoag Canc Ctr, Newport Beach, CA 92658 USA Hoag Canc Ctr Newport Beach CAUSA 92658 Ctr, Newport Beach, CA 92658 USA Rocky Mt Canc Ctr, Denver, CO USA Rocky Mt Canc Ctr Denver CO USARocky Mt Canc Ctr, Denver, CO USA
Titolo Testata:
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
fascicolo: 1, volume: 16, anno: 2001,
pagine: 47 - 54
SICI:
1084-9785(200102)16:1<47:TOKCWA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT INTERLEUKIN-2; RETROVIRAL VECTOR; IN-VITRO; THERAPY; SURVIVAL; SURGERY; GENE; IMMUNOTHERAPY; TRANSDUCTION; CULTURES;
Keywords:
kidney cancer; renal cell carcinoma; vaccines; cell cultures; cell lines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Dillman, RO Hoag Canc Ctr, 1 Hoag Dr,Bldg 41, Newport Beach, CA 92658 USA Hoag Canc Ctr 1 Hoag Dr,Bldg 41 Newport Beach CA USA 92658 USA
Citazione:
R.O. Dillman et al., "Treatment of kidney cancer with autologous tumor cell vaccines of short-term cell lines derived from renal cell carcinoma", CANC BIO R, 16(1), 2001, pp. 47-54

Abstract

Background. We established short-term cultures of autologous tumors from patients with renal carcinoma for use as active specific immunotherapy (i.e., autologous vaccine). Methods, Between 9/91 and 9/99 the cell biology laboratory of the Hoag Cancer Center received 69 kidney tumor samples that had been surgically excised, including 43 primary tumors and 26 metastatic lesions. Efforts were madeto establish short-term tumor cell cultures to use as autologous tumor cell vaccines. Prior to treatment patients underwent a baseline skin test for delayed tumor hypersensitivity (DTH) and then received s.c, injections of 10 million irradiated tumor cells that were given with various adjuvants weekly x 3 and then monthly x 5. Results. Cell lines were established for 55/69 patients (80%) including 36/43 (84%) from primary tumors and 19/26 (73%) from distant metastases. Vaccines were prepared for 41 patients; 27 were treated At the time of this analysis, follow up data was available for 26 patients with a median follow up> 5 years. Treatment was well-tolerated Of 10 patients who had no evident disease at the time of treatment, nine were alive 1-8 years later; 5/8 had conversion of their DTH test from negative to positive. For 16 patients with measurable metastatic disease at the time of treatment, there were no objective tumor responses; their median survival was 5.0 months. Among these 16 patients, only 1/8 DTH tests converted, but three had a positive baselineDTH test; one was previously treated with interleukin-2 and tumor infiltrating lymphocytes and two others were previously treated with autolymphocytetherapy. Conclusions. Vaccine therapy with short-term cultures of autologous tumor cells is feasible, weld-tolerated and associated with conversion of DTH andlong-term survival in patients who are free of disease at the time treatment is initiated However, significant anti-tumor responses were not seen in patients with mensurable disease at the time vaccine treatment was initiated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 13:00:48