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Titolo:
Synergistic analgesic effects of intrathecal midazolam and NMDA or AMPA receptor antagonists in rats
Autore:
Nishiyama, T; Gyermek, L; Lee, C; Kawasaki-Yatsugi, S; Yamaguchi, T;
Indirizzi:
Univ Tokyo, Inst Med Sci, Dept Surg Canc, Tokyo, Japan Univ Tokyo Tokyo Japan okyo, Inst Med Sci, Dept Surg Canc, Tokyo, Japan Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Dept Anesthesiol, Torrance, CA USA Univ Calif Los Angeles Torrance CA USA ept Anesthesiol, Torrance, CA USA Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Ibaraki, Osaka, Japan Yamanouchi Pharmaceut Co Ltd Ibaraki Osaka Japan , Ibaraki, Osaka, Japan
Titolo Testata:
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
fascicolo: 3, volume: 48, anno: 2001,
pagine: 288 - 294
SICI:
0832-610X(200103)48:3<288:SAEOIM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; SPINAL-CORD; NOCICEPTIVE RESPONSE; GLUTAMATE; FORMALIN; MORPHINE; NEURONS; ANTINOCICEPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Nishiyama, T 3-2-6-603 Kawaguchi, Kawaguchishi, Saitama 3320015, Japan 3-2-6-603 Kawaguchi Kawaguchishi Saitama Japan 3320015 Japan
Citazione:
T. Nishiyama et al., "Synergistic analgesic effects of intrathecal midazolam and NMDA or AMPA receptor antagonists in rats", CAN J ANAES, 48(3), 2001, pp. 288-294

Abstract

Purpose: To investigate the interaction of midazolam and N-methyl-D-aspartate (NMDA) receptor or -amino3- hydroxy-5-methyl isoxazole-4-propionic acid(AMPA) receptor antagonist on the effects of persistent inflammatory nociceptive activation. Methods: Male Sprague-Dawley rats were implanted with lumbar intrathecal catheters and were tested for their responses to subcutaneous formalin injection into the hindpaw. Saline, midazolam (1 to 100 ug), AP-5 (1 to 30 mug),a NMDA receptor antagonist, or YM872 (0.3 to 30 mug), an AMPA receptor antagonist was injected intrathecally 10 min before formalin injection. The combinations of midazolam and AP-5 or YM872 in a constant dose ratio based onthe 50% effective dose (ED50) were also tested and were analysed with an isobologram. Results: Dose-dependent effects were observed with midazolam (ED50 was 1.34 mug and 1.2 1 mug in phase 1 and 2 of the formalin test, respectively), AP-5 (7.64 mug and 1.4 mug) and YM872 (0.24 mug and 0.2 1 mug). Synergistic effects in both phases were obtained when combining midazolam with AP-5 or YM872. The ED50 of midazolam decreased to 0.012 mug (phase 1) and 0.27 mug (phase 2) with AP-5 and to 0.09 mug (phase 2) and 0.35 mug (phase 2) with YM872 (P < 0.01). Conclusions: These results suggest a functional coupling of benzodiazepine-aminobutyric acid (GABA)(A) receptor with NMDA and AMPA receptors in acuteand persistent inflammatory nociceptive mechanisms in the spinal cord.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:06:25