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Titolo:
False-positive serological tests in acute malaria
Autore:
Ghosh, K; Javeri, KN; Mohanty, D; Parmar, BD; Surati, RR; Joshi, SH;
Indirizzi:
Indian Council Med Res, Inst Immunohaematol, Bombay 400012, Maharashtra, India Indian Council Med Res Bombay Maharashtra India 400012 Maharashtra, India New Civil Hosp, Dept Med, Govt Med Coll, Surat, Gujrat, India New Civil Hosp Surat Gujrat India d, Govt Med Coll, Surat, Gujrat, India
Titolo Testata:
BRITISH JOURNAL OF BIOMEDICAL SCIENCE
fascicolo: 1, volume: 58, anno: 2001,
pagine: 20 - 23
SICI:
0967-4845(2001)58:1<20:FSTIAM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-CAPTURE ASSAY; FALCIPARUM-MALARIA; DIAGNOSIS; INFECTIONS; ANTIBODIES; MITOGEN;
Keywords:
Coombs' test; HIV seroprevalence; malaria; serologic tests; syphilis; rheumatoid factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Ghosh, K Indian Council Med Res, Inst Immunohaematol, 13th Floor,KEM Hosp MS Bldg, Bombay 400012, Maharashtra, India Indian Council Med Res 13th Floor,KEM Hosp MS Bldg Bombay Maharashtra India 400012
Citazione:
K. Ghosh et al., "False-positive serological tests in acute malaria", BR J BIOMED, 58(1), 2001, pp. 20-23

Abstract

A range of serological tests, including rapid plasma reagin (RPR), Widal test, enzyme-linked immunosorbent assay (ELISA) for human immunodeficiency virus (HIV)-1 and -2, direct Coombs' test (DCT), and rheumatoid factor (RF) were performed in a well-characterised cohort of 100 patients with acute malaria (Plasmodium vivax: infection: 31 patients; P. falciparum infection: 69 patients). Twenty-five healthy volunteers from a similar area were used as controls. Three patients from the severe P, falciparum group died, the remainder of the patients recovered completely. A large proportion of these patients showed false-positive serological reactions during the acute stage of infection, which became negative on re-testing, four weeks after recovery. In tropical countries such as India, where malaria is endemic, results of serological tests should be interpreted with caution in a patient with pyrexia of unknown origin (PUO).

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Documento generato il 27/11/20 alle ore 09:35:38